STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AprtAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)    
Predicted Functional Partners:
AdSL
Adenylosuccinate Lyase (AdSL) encodes a protein that might be a lyase involved in purine nucleotide metabolic process based on orthology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.993
bur
Burgundy, isoform B; Burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7.
  
 0.993
CG11089
RE29555p; IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity. It is involved in the biological process described with: wound healing; 'de novo' IMP biosynthetic process.
  
 0.989
AMPdeam
AMP deaminase activity. It is involved in the biological process described with: IMP biosynthetic process; IMP salvage; AMP metabolic process; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
  
 0.981
Adk2
Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process.
  
 0.976
Ak2
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways; Belongs to the adenylate kinase family. AK2 subfamily.
  
 
 0.973
CG11811
GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process.
  
 
 0.967
Ak1
ATP binding; adenylate kinase activity; uridylate kinase activity; Belongs to the adenylate kinase family.
  
 
 0.966
Gart
Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family.
  
 
 0.965
Adk1
AT16233p; Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process.
  
 0.962
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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