STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cf2Chorion factor 2 (Cf2) encodes a zinc-finger DNA-binding transcription factor that is involved in follicle cell fate determination and regulation of myogenic gene expression. (537 aa)    
Predicted Functional Partners:
rl
Mitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.
    
  0.902
CG33969
RE11703p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process.
      
 0.665
Mef2
Myocyte-specific enhancer factor 2; Transcription factor that could be a key player in early mesoderm differentiation and may be required for subsequent cell fate specifications within the somatic and visceral/heart mesodermal layers. Essential for myoblast fusion and consequently muscle formation in adults. During embryonic and pupal development, binds to the enhancer of the myoblast fusion gene sing and activates its transcription. Belongs to the MEF2 family.
   
 
 0.665
CG8281
GM10231p.
      
 0.601
Act79B
Actin, larval muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family.
    
 
 0.584
Act57B
Actin-57B; Actin 57B (Act57B) is one of several actin genes in the Drosophila genome, and one of the few that encode myofibrillar actin. This essential gene is a transcriptional target of Mef2 and Cf2 and is expressed in all embryonic muscles and a subset of adult muscle.
    
 
 0.546
bon
Bonus, isoform C; Bonus (bon) encodes a nuclear receptor cofactor involved in axon guidance and chromatin organization.
   
 0.542
sals
Sarcomere length short (sals) encodes an actin binding protein that promotes sarcomeric actin filament elongation from pointed ends during muscle growth.
    
 
 0.525
CG8159
RT10616p; Zinc ion binding; DNA-binding transcription factor activity; DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
  
  
 
0.522
prg
Piragua, isoform A; Piragua (prg) encodes a transcription factor that interacts genetically with fwe. It is required for embryonic dorsal closure and head involution as well as thorax and eye imaginal development.
  
  
 
0.522
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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