| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AdSS | Ass | FBpp0083395 | FBpp0307951 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | ATP binding; argininosuccinate synthase activity. It is involved in the biological process described with: arginine biosynthetic process; argininosuccinate metabolic process; urea cycle; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.970 |
| AdSS | CG32576 | FBpp0083395 | FBpp0100008 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | Uncharacterized protein, isoform B; It is involved in the biological process described with: vesicle-mediated transport. | 0.735 |
| AdSS | Dhod | FBpp0083395 | FBpp0289671 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | Dihydroorotate dehydrogenase (Dhod) encodes a protein that is associated with the inner mitochondrial membrane. It catalyzes the fourth step of de novo pyrimidine biosynthesis, which is required for normal cuticle formation and oogenesis. | 0.726 |
| AdSS | Gfat1 | FBpp0083395 | FBpp0291990 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | Glutamine:fructose-6-phosphate aminotransferase 1, isoform A; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: carbohydrate derivative biosynthetic process. | 0.555 |
| AdSS | Gfat2 | FBpp0083395 | FBpp0084666 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | Glutamine:fructose-6-phosphate aminotransferase 2; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; protein N-linked glycosylation. | 0.555 |
| AdSS | Prat | FBpp0083395 | FBpp0293248 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase (Prat) encodes a type-2 glutamine amidotransferase that converts phosphoribosylpyrophosphate to phosphoribosylamine using glutamine. It is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.778 |
| AdSS | Prat2 | FBpp0083395 | FBpp0076654 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase 2 (Prat2) encodes a type-2 glutamine amidotransferase that is essential in the pathway for de novo synthesis of inosine monophosphate (IMP). IMP is the precursor for purine nucleotides that are required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.775 |
| AdSS | r | FBpp0083395 | FBpp0088675 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | Glutamine-dependent carbamoyl-phosphate synthase; Rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy. | 0.985 |
| AdSS | su(r) | FBpp0083395 | FBpp0071273 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | Suppressor of rudimentary (su(r)) encodes a dihydropyrimidine dehydrogenase, the first step of pyrimidine catabolism. su(r) depletion does not produce visible phenotypes, but synergistic effects are exhibited by combining mutants with genes affecting pyrimidine biosynthesis and beta-alanine metabolism. | 0.620 |
| Ass | AdSS | FBpp0307951 | FBpp0083395 | ATP binding; argininosuccinate synthase activity. It is involved in the biological process described with: arginine biosynthetic process; argininosuccinate metabolic process; urea cycle; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | 0.970 |
| Ass | CG9674 | FBpp0307951 | FBpp0297083 | ATP binding; argininosuccinate synthase activity. It is involved in the biological process described with: arginine biosynthetic process; argininosuccinate metabolic process; urea cycle; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Uncharacterized protein, isoform F; It is involved in the biological process described with: glutamate biosynthetic process; ammonia assimilation cycle; oxidation-reduction process. | 0.618 |
| Ass | Prat | FBpp0307951 | FBpp0293248 | ATP binding; argininosuccinate synthase activity. It is involved in the biological process described with: arginine biosynthetic process; argininosuccinate metabolic process; urea cycle; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase (Prat) encodes a type-2 glutamine amidotransferase that converts phosphoribosylpyrophosphate to phosphoribosylamine using glutamine. It is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.550 |
| Ass | Prat2 | FBpp0307951 | FBpp0076654 | ATP binding; argininosuccinate synthase activity. It is involved in the biological process described with: arginine biosynthetic process; argininosuccinate metabolic process; urea cycle; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase 2 (Prat2) encodes a type-2 glutamine amidotransferase that is essential in the pathway for de novo synthesis of inosine monophosphate (IMP). IMP is the precursor for purine nucleotides that are required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.558 |
| Ass | r | FBpp0307951 | FBpp0088675 | ATP binding; argininosuccinate synthase activity. It is involved in the biological process described with: arginine biosynthetic process; argininosuccinate metabolic process; urea cycle; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Glutamine-dependent carbamoyl-phosphate synthase; Rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy. | 0.998 |
| CG32576 | AdSS | FBpp0100008 | FBpp0083395 | Uncharacterized protein, isoform B; It is involved in the biological process described with: vesicle-mediated transport. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. | 0.735 |
| CG32576 | Dhod | FBpp0100008 | FBpp0289671 | Uncharacterized protein, isoform B; It is involved in the biological process described with: vesicle-mediated transport. | Dihydroorotate dehydrogenase (Dhod) encodes a protein that is associated with the inner mitochondrial membrane. It catalyzes the fourth step of de novo pyrimidine biosynthesis, which is required for normal cuticle formation and oogenesis. | 0.938 |
| CG32576 | Gfat1 | FBpp0100008 | FBpp0291990 | Uncharacterized protein, isoform B; It is involved in the biological process described with: vesicle-mediated transport. | Glutamine:fructose-6-phosphate aminotransferase 1, isoform A; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: carbohydrate derivative biosynthetic process. | 0.415 |
| CG32576 | Gfat2 | FBpp0100008 | FBpp0084666 | Uncharacterized protein, isoform B; It is involved in the biological process described with: vesicle-mediated transport. | Glutamine:fructose-6-phosphate aminotransferase 2; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; protein N-linked glycosylation. | 0.415 |
| CG32576 | Prat | FBpp0100008 | FBpp0293248 | Uncharacterized protein, isoform B; It is involved in the biological process described with: vesicle-mediated transport. | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase (Prat) encodes a type-2 glutamine amidotransferase that converts phosphoribosylpyrophosphate to phosphoribosylamine using glutamine. It is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.584 |
| CG32576 | Prat2 | FBpp0100008 | FBpp0076654 | Uncharacterized protein, isoform B; It is involved in the biological process described with: vesicle-mediated transport. | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase 2 (Prat2) encodes a type-2 glutamine amidotransferase that is essential in the pathway for de novo synthesis of inosine monophosphate (IMP). IMP is the precursor for purine nucleotides that are required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.584 |