Protein pangolin, isoform J; Pangolin (pan) encodes an HMG-domain transcription factor that is a key component of the canonical Wingless signaling pathway. It toggles between acting as a transcriptional repressor (when bound to the product of gro) and activator (when bound to the product of arm) to promote cell fate specification.

Adenomatous polyposis coli 2 (Apc2) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary APC family member during embryonic development, and functions redundantly with the product of Apc in adult development.

Axin (Axn) encodes the key scaffolding protein for the canonical Wnt signalling pathway. In the absence of signal, it targets the product of arm for proteolysis inhibiting Wnt signalling. In the presence of signal, it forms a part of the membrane activation complex, disrupting the product of arm degradation. This pathway play roles in cell proliferation (imaginal disc), differentiation (embryonic patterning), death and stemness.

DE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...]

Protein kinase shaggy; Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering c [...]

APC-like, isoform A; APC-like (Apc) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary family member during CNS and eye development, and functions redundantly with the product of Apc2 in adult development.

Supernumerary limbs (slmb) encodes an essential, conserved F-box protein and a component of the SCF (Skp/Cullin/F-box) E3 ubiquitin-ligase, providing substrate specificity to the SCF. It negatively regulates multiple signaling pathways and cellular processes by promoting the proteasome-mediated degradation or cleavage of its targets, including the products of arm and ci (Wg and Hh signaling), SAK, per and Cap-H2.

Pygopus (pygo) encodes a key nuclear component of the Wnt signaling pathway. It facilitates the recruitment of the product of arm to Wnt-responsive genes by interacting with the transcription cofactor encoded by Chi. It also binds the product of lgs and the methylated tail of the product of His3. Together, they associate with the product of arm in a process that may function as a transition from gene silence to Wnt-induced transcription.

Protein BCL9 homolog; Legless (lgs) encodes a conserved transcriptional cofactor of the product of arm that is essential for the transcription of Wingless target genes. It contributes to growth regulation, cell survival and developmental patterning.