| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG12054 | Hr78 | FBpp0085120 | FBpp0089291 | LD46863p; Nucleic acid binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II. | Hormone-receptor-like in 78 (Hr78) encodes a protein induced above a basal level by 20-hydroxyecdysone. Hr78 mutants die during mid-larval stages with defects in molting of the tracheal cuticle; Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.832 |
| CG13287 | CG30020 | FBpp0303119 | FBpp0087330 | Uncharacterized protein, isoform B; Transcription corepressor activity; nucleic acid binding; chromatin binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated. | LD40262p; Zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA binding; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; regulation of gene expression. | 0.834 |
| CG13287 | Hr39 | FBpp0303119 | FBpp0081008 | Uncharacterized protein, isoform B; Transcription corepressor activity; nucleic acid binding; chromatin binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated. | Hormone receptor-like in 39 (Hr39) encodes a nuclear hormone receptor protein in subfamily 5. It is a master regulator of female reproductive gland development from the bipotential genital disc, and in adults is required for reproductive gland secretion, ovulation and additional functions. | 0.506 |
| CG13287 | Hr78 | FBpp0303119 | FBpp0089291 | Uncharacterized protein, isoform B; Transcription corepressor activity; nucleic acid binding; chromatin binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated. | Hormone-receptor-like in 78 (Hr78) encodes a protein induced above a basal level by 20-hydroxyecdysone. Hr78 mutants die during mid-larval stages with defects in molting of the tracheal cuticle; Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.630 |
| CG30020 | CG13287 | FBpp0087330 | FBpp0303119 | LD40262p; Zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA binding; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; regulation of gene expression. | Uncharacterized protein, isoform B; Transcription corepressor activity; nucleic acid binding; chromatin binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated. | 0.834 |
| CG30020 | Hr78 | FBpp0087330 | FBpp0089291 | LD40262p; Zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA binding; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; regulation of gene expression. | Hormone-receptor-like in 78 (Hr78) encodes a protein induced above a basal level by 20-hydroxyecdysone. Hr78 mutants die during mid-larval stages with defects in molting of the tracheal cuticle; Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.612 |
| EcR | Hnf4 | FBpp0291631 | FBpp0079350 | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.686 |
| EcR | Hr38 | FBpp0291631 | FBpp0080927 | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. | Hormone receptor-like in 38 (Hr38) encodes a protein that can heterodimerize with the U adult cuticle and for the proper uptake and storage of glycogen in larvae; Belongs to the nuclear hormone receptor family. NR4 subfamily. | 0.712 |
| EcR | Hr39 | FBpp0291631 | FBpp0081008 | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. | Hormone receptor-like in 39 (Hr39) encodes a nuclear hormone receptor protein in subfamily 5. It is a master regulator of female reproductive gland development from the bipotential genital disc, and in adults is required for reproductive gland secretion, ovulation and additional functions. | 0.702 |
| EcR | Hr78 | FBpp0291631 | FBpp0089291 | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. | Hormone-receptor-like in 78 (Hr78) encodes a protein induced above a basal level by 20-hydroxyecdysone. Hr78 mutants die during mid-larval stages with defects in molting of the tracheal cuticle; Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.612 |
| EcR | Hr96 | FBpp0291631 | FBpp0084131 | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. | Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.573 |
| EcR | Smr | FBpp0291631 | FBpp0305909 | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. | Smrter, isoform G; It is involved in the biological process described with: wing disc development; regulation of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; ovarian follicle cell development. | 0.997 |
| EcR | ftz-f1 | FBpp0291631 | FBpp0074853 | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. | Nuclear hormone receptor FTZ-F1; Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand; Belongs to the nuclear hormone receptor family. NR5 subfamily. | 0.803 |
| Hnf4 | EcR | FBpp0079350 | FBpp0291631 | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. | 0.686 |
| Hnf4 | Hr38 | FBpp0079350 | FBpp0080927 | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | Hormone receptor-like in 38 (Hr38) encodes a protein that can heterodimerize with the U adult cuticle and for the proper uptake and storage of glycogen in larvae; Belongs to the nuclear hormone receptor family. NR4 subfamily. | 0.548 |
| Hnf4 | Hr39 | FBpp0079350 | FBpp0081008 | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | Hormone receptor-like in 39 (Hr39) encodes a nuclear hormone receptor protein in subfamily 5. It is a master regulator of female reproductive gland development from the bipotential genital disc, and in adults is required for reproductive gland secretion, ovulation and additional functions. | 0.634 |
| Hnf4 | Hr78 | FBpp0079350 | FBpp0089291 | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | Hormone-receptor-like in 78 (Hr78) encodes a protein induced above a basal level by 20-hydroxyecdysone. Hr78 mutants die during mid-larval stages with defects in molting of the tracheal cuticle; Belongs to the nuclear hormone receptor family. NR2 subfamily. | 0.647 |
| Hnf4 | Hr96 | FBpp0079350 | FBpp0084131 | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis; Belongs to the nuclear hormone receptor family. NR1 subfamily. | 0.704 |
| Hnf4 | Smr | FBpp0079350 | FBpp0305909 | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | Smrter, isoform G; It is involved in the biological process described with: wing disc development; regulation of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; ovarian follicle cell development. | 0.551 |
| Hnf4 | ftz-f1 | FBpp0079350 | FBpp0074853 | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. | Nuclear hormone receptor FTZ-F1; Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand; Belongs to the nuclear hormone receptor family. NR5 subfamily. | 0.603 |