STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
shdEcdysone 20-monooxygenase; Shade (shd) encodes 20-hydroxylase and is responsible for converting Ecdysone into 20-hydroxyecdysone, the active form of the steroid. It is required in all tissues that produce active Ecdysone and thus contributes to larval moulting, metamorphosis, growth, neuroblast diversity and egg chamber maturation; Belongs to the cytochrome P450 family. (540 aa)    
Predicted Functional Partners:
Eo
Ecdysone oxidase (Eo) encodes an enzyme involved in ecdysone metabolism.
   
 
 0.981
Cyp18a1
Cytochrome P450-18a1 (Cyp18a1) encodes a P450 enzyme that inactivates the hormone 20 hydroxy ecdysone through addition of an OH group to the 26 carbon of the hormone molecule. It is expressed in many larval tissues. Cyp18a1 mutants result in prepupal lethality due to improper activation kinetics of the transcription factor encoded by ftz-f1.
  
0.954
sad
Shadow (sad) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It shows a mitochondrial localization and catalyzes the addition of a hydroxyl group to the 2 carbon of the cholesterol ring. sad mutants fail to undergo head involution, dorsal closure or to secrete cuticle.
  
  
0.954
nvd
Rieske-domain protein Neverland; Neverland (nvd) encodes an evolutionarily conserved oxygenase-like protein that is required for the biosynthesis pathway of ecdysone. It converts cholesterol to 7-dehydrocholesterol.
  
  
 0.918
Cyp6t3
Probable cytochrome P450 6t3; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 
 0.841
sro
Shroud (sro) encodes a short-chain dehydrogenase/reductase that is essential for ecdysone biosynthesis. It is hypothesized to work in the conversion of 7-dehydrocholesterol to 5beta-ketodiol; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.837
Cyp303a1
Probable cytochrome P450 303a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.803
Cyp6g1
Cytochrome P450 6g1; Necessary and sufficient for resistance to insecticides DDT and imidacloprid. May be involved in the metabolism of insect hormones.
  
 
 0.724
Cyp305a1
Probable cytochrome P450 305a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.710
EcR
Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis.
    
 
 0.710
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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