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CrebA protein (fruit fly) - STRING interaction network
"CrebA" - Cyclic-AMP response element binding protein A in Drosophila melanogaster
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
CrebACyclic-AMP response element binding protein A (CrebA) is a leucine-zipper transcription factor. CrebA upregulates genes encoding protein components of the canonical secretory pathway and tissue-specific genes in the salivary gland and epidermis (516 aa)    
Predicted Functional Partners:
Atf6
Atf6, isoform C; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; protein homodimerization activity. It is involved in the biological process described with- regulation of transcription, DNA-templated (741 aa)
     
 
  0.727
Sec24CD
Secretory 24CD, isoform C; Zinc ion binding; transporter activity; signal sequence binding (1193 aa)
     
   
  0.724
CrebB-17A
Cyclic AMP response element-binding protein B; Isoform E is a PKA-dependent transcriptional activator. Isoform J is a direct antagonist of activation by isoform E in cell culture. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters; Belongs to the bZIP family. ATF subfamily (359 aa)
       
 
  0.665
Sec23
Secretory 23, isoform E; GTPase activator activity; zinc ion binding; Sar GTPase activator activity (781 aa)
           
  0.611
sage
Salivary gland-expressed bHLH is only expressed in the salivary gland in embryos. It works with fkh to activate expression of salivary gland specific gene products (secreted proteins and enzymes that modify the secreted proteins) (268 aa)
           
  0.542
Hcf
Host cell factor; May be involved in control of the cell cycle (1500 aa)
       
 
  0.501
CG31229
Mitochondrial import inner membrane translocase subunit Tim22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity) (195 aa)
           
  0.485
slo
Calcium-activated potassium channel slowpoke; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing, phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity, its interaction with both Slob [...] (1217 aa)
           
  0.481
S2P
Metallopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with- proteolysis; sterol regulatory element binding protein cleavage (508 aa)
           
  0.474
CG11137
annotation not available (166 aa)
           
  0.469
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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