STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
His3:CG33866Protein heterodimerization activity; nucleosomal DNA binding. It is involved in the biological process described with: nucleosome assembly. (136 aa)    
Predicted Functional Partners:
His4r
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 0.992
His4:CG31611
Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly.
 
 
 0.992
His4:CG33871
Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation.
 
 
 0.992
His4:CG33873
DNA binding; protein heterodimerization activity; histone binding. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation.
 
 
 0.992
His4:CG33875
Histone binding; protein heterodimerization activity; DNA binding. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly.
 
 
 0.992
His4:CG33883
Protein heterodimerization activity; DNA binding; histone binding. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation.
 
 
 0.992
His4:CG33885
Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation.
 
 
 0.992
His4:CG33887
Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly.
 
 
 0.992
His4:CG33889
Protein heterodimerization activity; DNA binding; histone binding. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation.
 
 
 0.992
His4:CG33891
Protein heterodimerization activity; DNA binding; histone binding. It is involved in the biological process described with: nucleosome assembly; DNA-templated transcription, initiation.
 
 
 0.992
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.