STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
His4:CG33887Histone binding; DNA binding; protein heterodimerization activity. It is involved in the biological process described with: DNA-templated transcription, initiation; nucleosome assembly. (103 aa)    
Predicted Functional Partners:
His3:CG31613
Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 0.992
His3:CG33803
Nucleosomal DNA binding; protein heterodimerization activity. It is involved in the biological process described with: nucleosome assembly.
 
 
 0.992
His3:CG33806
Nucleosomal DNA binding; protein heterodimerization activity. It is involved in the biological process described with: nucleosome assembly.
 
 
 0.992
His3:CG33809
Protein heterodimerization activity; nucleosomal DNA binding. It is involved in the biological process described with: nucleosome assembly.
 
 
 0.992
His3:CG33812
Nucleosomal DNA binding; protein heterodimerization activity. It is involved in the biological process described with: nucleosome assembly.
 
 
 0.992
His3:CG33815
Protein heterodimerization activity; nucleosomal DNA binding. It is involved in the biological process described with: nucleosome assembly.
 
 
 0.992
His3:CG33818
Nucleosomal DNA binding; protein heterodimerization activity. It is involved in the biological process described with: nucleosome assembly.
 
 
 0.992
His3:CG33821
Nucleosomal DNA binding; protein heterodimerization activity. It is involved in the biological process described with: nucleosome assembly.
 
 
 0.992
His3:CG33824
Protein heterodimerization activity; nucleosomal DNA binding. It is involved in the biological process described with: nucleosome assembly.
 
 
 0.992
His3:CG33827
Nucleosomal DNA binding; protein heterodimerization activity. It is involved in the biological process described with: nucleosome assembly.
 
 
 0.992
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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