STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
jhamtJuvenile hormone acid O-methyltransferase; O-methyltransferase that transfers a methyl group from S- adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis. Also able to methylate farnesoate to methyl farnesoate. (297 aa)    
Predicted Functional Partners:
Jheh1
Juvenile hormone epoxide hydrolase 1 (Jheh1) expression changes are associated with increased tolerance to oxidative stress; Belongs to the peptidase S33 family.
     
 0.983
Jheh3
Epoxide hydrolase; Catalyzes juvenile hormone hydrolysis. Belongs to the peptidase S33 family.
   
 
 0.979
Jheh2
Juvenile hormone epoxide hydrolase 2 (Jheh2) encodes an enzyme that hydrolyzes cis-stilbene oxide. Jheh2 expression changes are associated with increased tolerance to oxidative stress; Belongs to the peptidase S33 family.
     
 0.967
Aldh
Aldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol.
     
 0.932
Jhe
Carboxylic ester hydrolase; Juvenile hormone esterase (Jhe) encodes a juvenile-hormone esterase involved in response to ethanol, juvenile hormone catabolism and male mating behavior; Belongs to the type-B carboxylesterase/lipase family.
      
 0.910
CG31075
Uncharacterized protein, isoform B; Aldehyde dehydrogenase (NAD+) activity. It is involved in the biological process described with: oxidation-reduction process; pyruvate metabolic process.
     
  0.900
Rim
Rab3 interacting molecule (Rim) encodes a scaffolding protein at the synaptic active zone, with important roles in promoting neurotransmitter release.
    
 
 0.867
Hmgs
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
      
 0.844
Kr-h1
Kruppel homolog 1 (Kr-h1) encodes a transcriptional regulator involved in axon pathfinding, neurite and axon remodeling as well as pupal photoreceptor maturation. In all cases, the function of the product of Kr-h1 is linked to that of the 20-hydroxyecdysone hormone.
      
 0.843
Fpps
Farnesyl pyrophosphate synthase (Fpps) encodes a protein involved in germ cell migration; Belongs to the FPP/GGPP synthase family.
      
 0.842
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.