STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG4456Rhodanese domain-containing protein CG4456. (111 aa)    
Predicted Functional Partners:
Sod2
Superoxide dismutase 2 (Mn) (Sod2) encodes an enzyme that detoxifies superoxide radicals in mitochondria. The loss of Sod2 generates endogenous oxidative stress that results in reduced activity of critical mitochondrial enzymes, hypersensitivity to oxidative stress and neonatal lethality. A muscle restricted p38Kinase-Mef2-Sod2 signaling module influences life span and stress.
  
 
 0.847
mRpS29
Mitochondrial ribosomal protein S29; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; apoptotic process; translation.
   
   0.764
mRpL17
Mitochondrial ribosomal protein L17, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: translation; mitochondrial translation.
  
   0.756
mRpL21
Mitochondrial ribosomal protein L21, isoform A; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; translation.
  
 
 0.755
CG12129
LD21545p; RNA binding.
    
   0.754
mRpL3
Mitochondrial ribosomal protein L3; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; translation.
   
   0.750
RpS11
40S ribosomal protein S11; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uS17 family.
   
   0.748
mRpL13
39S ribosomal protein L13, mitochondrial; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: negative regulation of translation; mitochondrial translation; translation; Belongs to the universal ribosomal protein uL13 family.
  
   0.744
mRpL46
Mitochondrial ribosomal protein L46; Structural constituent of ribosome; hydrolase activity. It is involved in the biological process described with: mitochondrial translation.
   
   0.740
mRpL15
Mitochondrial ribosomal protein L15; Structural constituent of ribosome. It is involved in the biological process described with: translation; mitochondrial translation.
   
   0.740
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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