STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ppk11Pickpocket 11 (ppk11) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family. In the larval stage, it is expressed in the terminal organ for salt taste and tracheal cells for liquid clearance. It functions in salt taste in adult flies; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (516 aa)    
Predicted Functional Partners:
ppk16
Pickpocket 16; Sodium channel activity. It is involved in the biological process described with: regulation of synaptic activity; sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
  
 
0.821
ppk29
Pickpocket 29 (ppk29) encodes a putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone signaling and neuronal excitability.
      
 0.794
ppk
Amiloride-sensitive Na+ channel; Pickpocket (ppk) encodes an acid-sensing sodium channel from the degenerin/epithelial sodium channel (DEG/ENaC) family. It contributes to mechanical nociception, larval behavior and dendrite morphogenesis.
  
 
 
0.741
ppk17
Pickpocket 17, isoform A; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.679
ppk25
Pickpocket 25 (ppk25) encodes a DEG/ENaC channel subunit involved in male courtship behavior and pheromone detection; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.674
Gr66a
Gustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...]
      
 0.668
ppk10
Pickpocket 10; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.602
ppk15
Pickpocket 15; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
  
   
 0.585
Gr2a
Putative gustatory receptor 2a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its not yet determined substrates. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily.
      
 0.528
Ir76b
Ionotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit.
      
 0.523
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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