STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
loboCoiled-coil domain-containing protein lobo; Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility (By similarity). Involved in sperm motility. Required for the sperm to enter in the coiled storage seminal receptacle (SR) tubule. (897 aa)    
Predicted Functional Partners:
Gas8
Dynein regulatory complex subunit 4; Cytoskeletal linker which probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity); Belongs to the DRC4 family.
  
  
 0.808
CG10958
Dynein regulatory complex protein 1 homolog; It is involved in the biological process described with: regulation of cilium movement; axonemal dynein complex assembly; cilium-dependent cell motility; Belongs to the DRC1 family.
   
  
 0.639
Rsph4a
GH13165p; It is involved in the biological process described with: cilium movement; axoneme assembly.
  
  
 0.636
WDY
WD repeat-containing protein on Y chromosome; Histone binding. It is involved in the biological process described with: histone H3-K4 methylation.
      
 0.627
BBS1
Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.
      
 0.620
CG15642
IP07051p.
      
 0.601
Dnali1
Putative inner dynein arm light chain, axonemal; May play a dynamic role in flagellar motility.
  
  
 0.582
kl-2
Male fertility factor kl2; ATP binding; ATPase activity; dynein intermediate chain binding; dynein light intermediate chain binding; ATP-dependent microtubule motor activity, minus-end-directed. It is involved in the biological process described with: cilium movement; microtubule-based movement.
   
  
 0.542
CG5715
Metalloendopeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis.
      
 0.533
CG34290
Peptidase S1 domain-containing protein; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
      
 0.533
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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