STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
DhfrDihydrofolate reductase (Dhfr) encodes an NADPH-dependent enzyme used to convert folic acid and dihydrofolate to tetrahydrofolate, which is used as a cofactor for the biosynthesis of purines, thymidylate, and several amino acids. Dhfr product contributes to cell proliferation and cell growth. (182 aa)    
Predicted Functional Partners:
Ts
Thymidylate synthase activity. It is involved in the biological process described with: dTMP biosynthetic process.
 
 0.999
Shmt
Serine hydroxymethyl transferase (Shmt) encodes a conserved pyridoxal phosphate-containing enzyme that converts serine into glycine and N5,N10-methylentetrahydrofolate. This reaction represents a major source for activated C1 units and tetrahydrofolate-mediated C1 metabolism; Belongs to the SHMT family.
  
 
 0.984
pug
C-1-tetrahydrofolate synthase, cytoplasmic; Pugilist (pug) encodes the trifunctional enzyme methylenetetrahydrofolate dehydrogenase involved in the pigmentation of pteridines and ommochromes; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family.
  
 
 0.984
CG1750
Uncharacterized protein; methionyl-tRNA formyltransferase activity. It is involved in the biological process described with: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA; biosynthetic process.
  
 
 0.980
Gart
Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family.
  
 
 0.979
Fpgs
Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.
   
 
 0.978
CG11089
RE29555p; IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity. It is involved in the biological process described with: wound healing; 'de novo' IMP biosynthetic process.
  
 
 0.975
CG8665
Aldehyde dehydrogenase (NAD+) activity; formyltetrahydrofolate dehydrogenase activity; hydroxymethyl-, formyl- and related transferase activity. It is involved in the biological process described with: one-carbon metabolic process; biosynthetic process; oxidation-reduction process; 10-formyltetrahydrofolate catabolic process; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
  
 
 0.973
CG31773
AT16211p; Tetrahydrofolylpolyglutamate synthase activity; ATP binding. It is involved in the biological process described with: tetrahydrofolylpolyglutamate biosynthetic process; folic acid-containing compound biosynthetic process.
     
 0.972
Dhpr
NADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process.
   
 
 0.956
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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