STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SlmapSarcolemma associated protein, isoform A; Protein kinase binding. It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction. (897 aa)    
Predicted Functional Partners:
Fgop2
FGFR1 oncogene partner 2 homolog; It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction; Belongs to the SIKE family.
   
 0.996
Cka
Connector of kinase to AP-1, isoform E; Protein binding.
   
 0.995
Strip
Striatin interacting protein, isoform B; Striatin interacting protein (Strip) encodes an intracellular protein and component of the STRIPAK PP2A protein complex. It is involved in Hippo signaling, endosome maturation, and microtubule regulation.
   
 0.994
Naus
Uncharacterized protein CG10915; It is involved in the biological process described with: regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of neuron projection arborization; positive regulation of lamellipodium morphogenesis; actin filament bundle retrograde transport; protein localization to actin cytoskeleton.
     
 0.975
mts
Serine/threonine-protein phosphatase PP2A; Microtubule star (mts) encodes the catalytic subunit of protein phosphatase 2A. It is involved in various developmental processes and signaling pathways, such as Hh signaling and Wingless signaling; Belongs to the PPP phosphatase family. PP-2A subfamily.
  
 
 0.955
Mob4
MOB kinase activator 4 (Mob4) encodes a protein that contributes to microtubule organization, axonal transport, mitotic spindle assembly and regulation of Hippo signaling; Belongs to the MOB1/phocein family.
     
 0.940
Ccm3
Cerebral cavernous malformation 3 (Ccm3) encodes a small scaffolding protein that forms dimers with the product of GckIII. In the tracheal system, it is required specifically in terminal cells, and its loss is associated with tube dilation.
   
 
 0.938
Pp2A-29B
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit; Protein phosphatase 2A at 29B (Pp2A-29B) encodes the structural A subunit of the trimeric PP2A phosphatase enzyme. It links the catalytic C subunit encoded by mts and a variable regulatory B family subunit, which directs the enzyme to distinct substrates. The roles of Pp2A-29B product include centriole duplication, chromosome segregation, autophagy, axonal transport, growth regulation, and active zone stabilization.
    
 0.909
RpS27A
Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...]
    
 
 0.844
CG33791
GH27234p; Oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding. It is involved in the biological process described with: tricarboxylic acid cycle.
    
 
 0.839
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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