STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG9853Golgi to ER traffic protein 4 homolog; May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane. (339 aa)    
Predicted Functional Partners:
CG1598
ATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...]
   
 
 0.993
CG7546
Uncharacterized protein, isoform D; Enzyme binding; misfolded protein binding; polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: negative regulation of apoptotic process; ubiquitin-dependent ERAD pathway.
    
 0.984
Sgt
Small glutamine-rich tetratricopeptide containing protein (Sgt) encodes a protein involved in the regulation of the protein folding mediated by chaperones.
   
 0.982
CG7215
RE23139p1.
   
 0.912
Rad23
DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover.
   
 
 0.817
CG10694
AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process.
    
 
 0.808
CG17167
RE48874p; Calcium, potassium:sodium antiporter activity; calcium channel activity. It is involved in the biological process described with: calcium ion transmembrane transport; cellular calcium ion homeostasis; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
    
   0.729
zyd
Zydeco, isoform F; Zydeco (zyd) encodes a potassium-dependent sodium/calcium exchanger found in cortex glia. It is thought to serve as a key calcium export pathway to control calcium oscillations that occur in membrane microdomains of the glial cell; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
    
   0.729
Nckx30C
Sodium/potassium/calcium exchanger Nckx30C; May function in the removal and maintenance of calcium homeostasis during signaling in the adult and in signaling events during embryogenesis and patterning of imaginal disks. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
    
   0.729
CG12061
Uncharacterized protein, isoform D; Calcium, potassium:sodium antiporter activity; calcium channel activity. It is involved in the biological process described with: calcium ion transmembrane transport; cellular calcium ion homeostasis; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
    
   0.729
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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