node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG40228 | CG6220 | FBpp0112564 | FBpp0086776 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | 0.821 |
CG40228 | CG9915 | FBpp0112564 | FBpp0307918 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | Uncharacterized protein, isoform B; It is involved in the biological process described with: regulation of mRNA export from nucleus; regulation of histone H3-K36 trimethylation; regulation of mRNA processing. | 0.954 |
CG40228 | RpII140 | FBpp0112564 | FBpp0310926 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...] | 0.854 |
CG40228 | RpII215 | FBpp0112564 | FBpp0073387 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | 0.848 |
CG40228 | Rpb3 | FBpp0112564 | FBpp0080121 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | RNA polymerase II 33kD subunit; DNA-directed 5'-3' RNA polymerase activity; RNA polymerase II activity; protein dimerization activity; DNA binding. It is involved in the biological process described with: transcription by RNA polymerase II; cellular response to heat. | 0.851 |
CG40228 | Spt5 | FBpp0112564 | FBpp0085716 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development; Belongs [...] | 0.941 |
CG40228 | Spt6 | FBpp0112564 | FBpp0070861 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | Transcription elongation factor SPT6; Transcription elongation factor which binds histone H3 and enhances transcription elongation by RNA polymerase II (RNAPII). Required for the transcriptional induction of heat shock response genes and for maximal recruitment of two other elongation factors, Spt5 and Paf1, to the induced Hsp70. Plays a critical role in normal fly development throughout the lifecycle. | 0.834 |
CG40228 | dre4 | FBpp0112564 | FBpp0072743 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.870 |
CG40228 | hyx | FBpp0112564 | FBpp0289644 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | Hyrax, isoform A; Hyrax (hyx) encodes a protein recruited by signaling pathway specific transcriptional regulators such as the products of arm and ci and is important for the output of Wingless and Hedgehog pathways. | 0.821 |
CG40228 | spt4 | FBpp0112564 | FBpp0086953 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By simi [...] | 0.895 |
CG6220 | CG40228 | FBpp0086776 | FBpp0112564 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. | 0.821 |
CG6220 | CG9915 | FBpp0086776 | FBpp0307918 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | Uncharacterized protein, isoform B; It is involved in the biological process described with: regulation of mRNA export from nucleus; regulation of histone H3-K36 trimethylation; regulation of mRNA processing. | 0.582 |
CG6220 | RpII140 | FBpp0086776 | FBpp0310926 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...] | 0.892 |
CG6220 | RpII215 | FBpp0086776 | FBpp0073387 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] | 0.921 |
CG6220 | Rpb3 | FBpp0086776 | FBpp0080121 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | RNA polymerase II 33kD subunit; DNA-directed 5'-3' RNA polymerase activity; RNA polymerase II activity; protein dimerization activity; DNA binding. It is involved in the biological process described with: transcription by RNA polymerase II; cellular response to heat. | 0.871 |
CG6220 | Spt5 | FBpp0086776 | FBpp0085716 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development; Belongs [...] | 0.981 |
CG6220 | Spt6 | FBpp0086776 | FBpp0070861 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | Transcription elongation factor SPT6; Transcription elongation factor which binds histone H3 and enhances transcription elongation by RNA polymerase II (RNAPII). Required for the transcriptional induction of heat shock response genes and for maximal recruitment of two other elongation factors, Spt5 and Paf1, to the induced Hsp70. Plays a critical role in normal fly development throughout the lifecycle. | 0.941 |
CG6220 | dre4 | FBpp0086776 | FBpp0072743 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.978 |
CG6220 | hyx | FBpp0086776 | FBpp0289644 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | Hyrax, isoform A; Hyrax (hyx) encodes a protein recruited by signaling pathway specific transcriptional regulators such as the products of arm and ci and is important for the output of Wingless and Hedgehog pathways. | 0.754 |
CG6220 | spt4 | FBpp0086776 | FBpp0086953 | FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II. | Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By simi [...] | 0.962 |