STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nhe3Sodium/hydrogen exchanger; Sodium:proton antiporter activity; potassium:proton antiporter activity. It is involved in the biological process described with: regulation of intracellular pH; potassium ion transmembrane transport; sodium ion import across plasma membrane; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (711 aa)    
Predicted Functional Partners:
Nha1
Na[+]/H[+] hydrogen antiporter 1 (Nha1) encodes a chloride transmembrane transporter belonging to the CPA2 family of cation/proton antiporter family.
      
 0.689
Nha2
Na[+]/H[+] hydrogen antiporter 2 (Nha2) encodes a protein involved in the transmembrane transport of potassium.
      
 0.688
Moe
Moesin/ezrin/radixin homolog 1; Involved in connections of major cytoskeletal structures to the plasma membrane. Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr. In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles.
    
 
 0.655
P5CS
Delta-1-pyrroline-5-carboxylate synthase; Glutamate-5-semialdehyde dehydrogenase activity; glutamate 5-kinase activity; delta1-pyrroline-5-carboxylate synthetase activity. It is involved in the biological process described with: oxidation-reduction process; proline biosynthetic process; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
     
 0.637
CG33108
UPF0692 protein CG33108; Belongs to the UPF0692 family.
      
 0.626
NKCC
Sodium:potassium:chloride symporter activity; potassium:chloride symporter activity; sodium ion transmembrane transporter activity; sodium:chloride symporter activity; amino acid transmembrane transporter activity.
   
 
 0.624
NaPi-III
Na[+]-dependent inorganic phosphate cotransporter type III (NaPi-III) encodes a transporter involved in sodium-dependent phosphate transmembrane transport; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
   
 
 0.606
kcc
Kazachoc, isoform G; Kazachoc (kcc) encodes a potassium:chloride symporter that contributes to seizure susceptibility.
  
 
 0.588
Ncc69
Sodium chloride cotransporter 69 (Ncc69) encodes a member of the SLC12 family of Na[+]/K[+]/2Cl[-] cotransporters (NKCC).
   
 
 0.556
CG8777
LP07472p; It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process.
      
 0.536
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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