node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG6512 | ClpP | FBpp0075012 | FBpp0304498 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | 0.877 |
CG6512 | ClpX | FBpp0075012 | FBpp0310666 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | Uncharacterized protein, isoform C; ATP binding; ATPase activity; unfolded protein binding. It is involved in the biological process described with: protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression; protein folding. | 0.933 |
CG6512 | Lon | FBpp0075012 | FBpp0271918 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Regulates mitochondrial DNA (mtDNA) copy number and transcription by [...] | 0.856 |
CG6512 | Roe1 | FBpp0075012 | FBpp0086795 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). | 0.572 |
CG6512 | Spg7 | FBpp0075012 | FBpp0311759 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | Paraplegin, isoform A; Metallopeptidase activity; metalloendopeptidase activity; zinc ion binding; ATPase activity; ATP binding. It is involved in the biological process described with: mitochondrion organization; proteolysis. | 0.956 |
CG6512 | YME1L | FBpp0075012 | FBpp0293463 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...] | 0.751 |
ClpP | CG6512 | FBpp0304498 | FBpp0075012 | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | 0.877 |
ClpP | ClpX | FBpp0304498 | FBpp0310666 | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | Uncharacterized protein, isoform C; ATP binding; ATPase activity; unfolded protein binding. It is involved in the biological process described with: protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression; protein folding. | 0.999 |
ClpP | Gp93 | FBpp0304498 | FBpp0084623 | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | 0.718 |
ClpP | Hsp83 | FBpp0304498 | FBpp0305095 | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | 0.433 |
ClpP | Lon | FBpp0304498 | FBpp0271918 | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Regulates mitochondrial DNA (mtDNA) copy number and transcription by [...] | 0.970 |
ClpP | Roe1 | FBpp0304498 | FBpp0086795 | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). | 0.896 |
ClpP | Spg7 | FBpp0304498 | FBpp0311759 | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | Paraplegin, isoform A; Metallopeptidase activity; metalloendopeptidase activity; zinc ion binding; ATPase activity; ATP binding. It is involved in the biological process described with: mitochondrion organization; proteolysis. | 0.844 |
ClpP | Trap1 | FBpp0304498 | FBpp0085482 | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | Trap1, isoform A; Trap1 (Trap1) encodes a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction. | 0.605 |
ClpP | Tsc1 | FBpp0304498 | FBpp0083931 | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | LD23779p; Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. | 0.433 |
ClpP | YME1L | FBpp0304498 | FBpp0293463 | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...] | 0.851 |
ClpX | CG6512 | FBpp0310666 | FBpp0075012 | Uncharacterized protein, isoform C; ATP binding; ATPase activity; unfolded protein binding. It is involved in the biological process described with: protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression; protein folding. | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | 0.933 |
ClpX | ClpP | FBpp0310666 | FBpp0304498 | Uncharacterized protein, isoform C; ATP binding; ATPase activity; unfolded protein binding. It is involved in the biological process described with: protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression; protein folding. | ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression. | 0.999 |
ClpX | Gp93 | FBpp0310666 | FBpp0084623 | Uncharacterized protein, isoform C; ATP binding; ATPase activity; unfolded protein binding. It is involved in the biological process described with: protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression; protein folding. | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | 0.541 |
ClpX | Lon | FBpp0310666 | FBpp0271918 | Uncharacterized protein, isoform C; ATP binding; ATPase activity; unfolded protein binding. It is involved in the biological process described with: protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression; protein folding. | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Regulates mitochondrial DNA (mtDNA) copy number and transcription by [...] | 0.950 |