Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cdc42 | Dap160 | FBpp0301153 | FBpp0297159 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | 0.948 |
| Cdc42 | Eps-15 | FBpp0301153 | FBpp0072340 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. | 0.506 |
| Cdc42 | Rho1 | FBpp0301153 | FBpp0086354 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] | 0.694 |
| Cdc42 | capu | FBpp0301153 | FBpp0288517 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | Cappuccino (capu) encodes a formin family protein that nucleates actin filaments and accelerates their elongation. It works with the product of spir to build an actin mesh that fills the oocyte during mid-oogenesis. capu is necessary for polarity establishment and female fertility. | 0.901 |
| Cdc42 | chic | FBpp0301153 | FBpp0089196 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | Profilin; Chickadee (chic) encodes an actin monomer binding protein that provides the major cellular pool of readily polymerizing ATP-actin monomers. It is involved in oogenesis, spermatogenesis, cell division, bristle formation, cellular morphogenesis, axon growth, filopodia formation, dorsal closure, wound healing and stem cell maintenance. | 0.859 |
| Cdc42 | shi | FBpp0301153 | FBpp0305866 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.827 |
| Cdc42 | spir | FBpp0301153 | FBpp0080884 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | Protein spire; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Promotes dissociation of capu from the barbed end of actin filaments. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for localization of determinants within the developing oocyte to the posterior pole and to the dorsal anterior corner. Links Rho family signaling and Jnk function to the actin cytoskeleton. | 0.625 |
| Cdc42 | wash | FBpp0301153 | FBpp0308667 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | WASH complex subunit 1; Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. Participates in both linear- and branched-actin networks. Functions in linear-filament (bundled F-actin) by acting downstream of Rho1 and regulating actin and microtubule organization during oogenesis. Nucleates actin in an Arp2/3-dependent manner and exhibits F-actin and microtubule bundling and cross-linking activity in the egg chamber. During embryogenesis, acts downstream of Rho1 to activate the Arp2/3 complex which is necessary for the developmental migrat [...] | 0.400 |
| Dap160 | Cdc42 | FBpp0297159 | FBpp0301153 | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | 0.948 |
| Dap160 | Eps-15 | FBpp0297159 | FBpp0072340 | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. | 0.993 |
| Dap160 | Reps | FBpp0297159 | FBpp0079817 | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | RALBP1 associated Eps domain containing, isoform A; Calcium ion binding; protein binding. It is involved in the biological process described with: endosomal transport; endocytosis. | 0.866 |
| Dap160 | Rho1 | FBpp0297159 | FBpp0086354 | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] | 0.702 |
| Dap160 | capu | FBpp0297159 | FBpp0288517 | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | Cappuccino (capu) encodes a formin family protein that nucleates actin filaments and accelerates their elongation. It works with the product of spir to build an actin mesh that fills the oocyte during mid-oogenesis. capu is necessary for polarity establishment and female fertility. | 0.901 |
| Dap160 | shi | FBpp0297159 | FBpp0305866 | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.996 |
| Eps-15 | Cdc42 | FBpp0072340 | FBpp0301153 | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. | 0.506 |
| Eps-15 | Dap160 | FBpp0072340 | FBpp0297159 | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | 0.993 |
| Eps-15 | Reps | FBpp0072340 | FBpp0079817 | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. | RALBP1 associated Eps domain containing, isoform A; Calcium ion binding; protein binding. It is involved in the biological process described with: endosomal transport; endocytosis. | 0.860 |
| Eps-15 | capu | FBpp0072340 | FBpp0288517 | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. | Cappuccino (capu) encodes a formin family protein that nucleates actin filaments and accelerates their elongation. It works with the product of spir to build an actin mesh that fills the oocyte during mid-oogenesis. capu is necessary for polarity establishment and female fertility. | 0.812 |
| Eps-15 | shi | FBpp0072340 | FBpp0305866 | Epidermal growth factor receptor pathway substrate clone 15 (Eps-15) encodes a multi-domain adaptor protein involved in endocytosis. It interacts with several other endocytic factors such as those encoded by shi, stnB, Dap160 and AP-2alpha. It is enriched at sites of endocytosis and is required for normal synaptic bouton development and vesicle endocytosis during high frequency stimulation. | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.948 |
| Reps | Dap160 | FBpp0079817 | FBpp0297159 | RALBP1 associated Eps domain containing, isoform A; Calcium ion binding; protein binding. It is involved in the biological process described with: endosomal transport; endocytosis. | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | 0.866 |
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