STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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notUbiquitin carboxyl-terminal hydrolase nonstop; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of histone H2B, thereby acting as a coactivator in a large subset of genes. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad. Belongs to the peptidase C19 family. UBP8 subfamily. (496 aa)    
Predicted Functional Partners:
Saf6
SAGA factor-like TAF6 (Saf6) encodes a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Saf6 replaces the product of mia within SAGA when the product of mia is restricted to the TFIID transcription complex. Notably, the product of Saf6 is essential for SAGA's co-activator function but does not impact either of its enzymatic activities.
   
  0.999
Ada1-2
Transcriptional Adaptor 1-2 (Ada1-2) encodes a subunit of the SAGA chromatin modifying complex.
   
  0.999
wda
Will decrease acetylation (wda) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of wda is a component of the histone-acetyltransferase (HAT) module, and is essential for full HAT activity of the the product of Gcn5.
   
 0.999
Ada2b
Transcriptional adapter 2B; Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.
   
 0.999
Sgf11
SAGA-associated factor 11 homolog; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA- dependent manner. Bind [...]
   
 0.999
Sgf29
SAGA-associated factor 29kDa (Sgf29) encodes a encodes subunit of some chromatin modifying complexes.
   
 0.999
e(y)2
Enhancer of yellow 2 transcription factor; Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes. The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Involved in t [...]
   
 0.998
Gcn5
Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis.
   
 0.998
Spt3
FI01013p; Spt3 (Spt3) encodes a encodes a subunit of the SAGA chromatin modifying complex.
   
 0.998
Nipped-A
Transcription-associated protein 1; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double- strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. During wing development, required for activity of Notch and its coactivator mam. Function in promoting mam function is likely to involve both the Tip60 and SAGA complexes.
   
 0.996
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.