STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bunProtein bunched, class 2/F/G isoform; Probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis. May be required for the transmission of the dpp signal and for a morphogenetic movement of the medulla in the brain that reorients the second optic lobe relative to the first. Plays a role in determining proper dorsal cell fates leading to the formation of the dorsal appendages. (1331 aa)    
Predicted Functional Partners:
Madm
Nuclear receptor-binding protein homolog; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus.
    
 
 0.790
CG15696
RT01055p1; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
    
 
 0.530
CG31817
Uncharacterized protein.
      
 0.529
aop
Ets DNA-binding protein pokkuri; Anterior open (aop) encodes a transcriptional repressor of the ETS family. It acts downstream of receptor tyrosine kinase signaling to regulate cell fate transitions critical to the development of many tissues including the nervous system, heart, trachea and eye.
   
 
 0.521
CG17786
RE01338p.
      
 0.512
CG30384
Uncharacterized protein.
      
 0.495
CG9044
Uncharacterized protein, isoform C; Protein kinase binding. It is involved in the biological process described with: protein localization.
   
  
 0.495
CG32521
GH09530p.
      
 0.493
Gmd
GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
      
 0.493
CG7386
FI21277p1; DNA binding; zinc ion binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated.
    
 
 0.461
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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