Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup.

Uncharacterized protein, isoform A.

Uncharacterized protein, isoform A; RNA polymerase II repressing transcription factor binding; histone deacetylase binding; transcription corepressor activity; DNA binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II.

Histone deacetylase HDAC1; Catalyzes the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). In the larval brain, part of a regulatory network including the transcript [...]

Histone deacetylase 3 (HDAC3) encodes a histone deacetylase involved in chromatin silencing. It controls cell growth through apoptosis suppression by regulating transcription of hid; Belongs to the histone deacetylase family. HD Type 1 subfamily.

Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway.

Trimethylguanosine synthase 1 (Tgs1) encodes an essential cytoplasmic enzyme that hypermethylates the 7-methylguanosine cap of snRNPs to a 2,2,7-trimethylguanosine cap. It is required in the motor system for viability and motor behaviour.

GH11784p.

Coilin; Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. Required for Cajal body formation. Belongs to the coilin family.