node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG14184 | CG14812 | FBpp0074641 | FBpp0305695 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | 0.999 |
CG14184 | CG14977 | FBpp0074641 | FBpp0303128 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Ragulator complex protein LAMTOR4 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. | 0.999 |
CG14184 | CG5110 | FBpp0074641 | FBpp0297292 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Ragulator complex protein LAMTOR3 homolog; CG5110 encodes a scaffold protein that associates with the MAP kinase kinase and the MAP kinase encoded by Mekk1 and rl respectively. It regulates the vein promoting function of rl during wing imaginal disc development in third instar larvae; Belongs to the LAMTOR3 family. | 0.999 |
CG14184 | CG5189 | FBpp0074641 | FBpp0289083 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Belongs to the GAMAD family. | 0.999 |
CG14184 | CG8500 | FBpp0074641 | FBpp0081617 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | FI18258p1; GDP binding; GTPase activity; GTP binding. It is involved in the biological process described with: small GTPase mediated signal transduction. | 0.627 |
CG14184 | Nprl2 | FBpp0074641 | FBpp0074122 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | GATOR complex protein NPRL2; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid o [...] | 0.629 |
CG14184 | RagA-B | FBpp0074641 | FBpp0081491 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Ras-related GTP binding A/B (RagA-B) encodes a Ras family GTPase that forms a heterodimer with the product of RagC-D. The heterodimer localizes on the lysosome surface and functions to relay amino acid signals to activate the product of Tor by recruiting it to the lysosome. | 0.994 |
CG14184 | RagC-D | FBpp0074641 | FBpp0087883 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Protein heterodimerization activity; GTP binding; GTPase activity. It is involved in the biological process described with: regulation of autophagy; positive regulation of TOR signaling; cellular response to starvation; positive regulation of TORC1 signaling; cellular response to amino acid stimulus. | 0.995 |
CG14184 | Tor | FBpp0074641 | FBpp0307598 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] | 0.894 |
CG14184 | raptor | FBpp0074641 | FBpp0311819 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. | 0.989 |
CG14812 | CG14184 | FBpp0305695 | FBpp0074641 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | 0.999 |
CG14812 | CG14977 | FBpp0305695 | FBpp0303128 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | Ragulator complex protein LAMTOR4 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. | 0.999 |
CG14812 | CG5110 | FBpp0305695 | FBpp0297292 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | Ragulator complex protein LAMTOR3 homolog; CG5110 encodes a scaffold protein that associates with the MAP kinase kinase and the MAP kinase encoded by Mekk1 and rl respectively. It regulates the vein promoting function of rl during wing imaginal disc development in third instar larvae; Belongs to the LAMTOR3 family. | 0.999 |
CG14812 | CG5189 | FBpp0305695 | FBpp0289083 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Belongs to the GAMAD family. | 0.999 |
CG14812 | Nprl2 | FBpp0305695 | FBpp0074122 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | GATOR complex protein NPRL2; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid o [...] | 0.836 |
CG14812 | RagA-B | FBpp0305695 | FBpp0081491 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | Ras-related GTP binding A/B (RagA-B) encodes a Ras family GTPase that forms a heterodimer with the product of RagC-D. The heterodimer localizes on the lysosome surface and functions to relay amino acid signals to activate the product of Tor by recruiting it to the lysosome. | 0.998 |
CG14812 | RagC-D | FBpp0305695 | FBpp0087883 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | Protein heterodimerization activity; GTP binding; GTPase activity. It is involved in the biological process described with: regulation of autophagy; positive regulation of TOR signaling; cellular response to starvation; positive regulation of TORC1 signaling; cellular response to amino acid stimulus. | 0.997 |
CG14812 | Tor | FBpp0305695 | FBpp0307598 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] | 0.871 |
CG14812 | raptor | FBpp0305695 | FBpp0311819 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. | 0.992 |
CG14977 | CG14184 | FBpp0303128 | FBpp0074641 | Ragulator complex protein LAMTOR4 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | 0.999 |