STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Ten-aTeneurin-a; Tenascin accessory (Ten-a) encodes a type II dimeric transmembrane protein with a extracellular domain that mediates homophilic interactions with itself and with the product of Ten-m. It also interacts intracellularly with cytoskeleton regulatory proteins. It regulates axon guidance in embryonic nervous system, synaptic partner matching as well as synaptic organization in olfactory and neuromuscular systems. (3387 aa)    
Predicted Functional Partners:
Cirl
Latrophilin Cirl; Latrotoxin receptor activity; G protein-coupled receptor activity; carbohydrate binding; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
  
 
 0.996
Ten-m
Teneurin-m; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with Ten-a to organize neuromuscular synapses. Functions in olfactory synaptic partner matching by promoting homophilic cell adhesion between pre- synaptic olfactory receptor neurons (ORN) axons and post-synaptic projection neurons (PN) dendrites partner in the developing antennal lobe to form stable connections. Also [...]
  
 
0.870
CG32655
MIP14002p.
      
 0.665
CG6867
FI21454p1; It is involved in the biological process described with: motor neuron axon guidance; synaptic target inhibition.
    
 
 0.648
Nrx-1
Neurexin 1, isoform F; Neurexin 1 (Nrx-1) encodes a transmembrane synaptic adhesive molecule that regulates the synaptic architecture and function in the brain and neuromuscular junction. It contributes to synaptic growth, transmission, synaptic formation and also regulation of learning and memory, locomotion and visual function.
   
  
 0.613
yip3
Yippee interacting protein 3, isoform A; Threonine-type endopeptidase activity. It is involved in the biological process described with: proteolysis involved in cellular protein catabolic process.
      
 0.564
CG2157
Uncharacterized protein, isoform B.
   
  
 0.524
cindr
CIN85 and CD2AP related (cindr) encodes an adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton. It regulates cytoskeletal dynamics, eye patterning and endocytosis. It also cooperates with the product of scra to promote intercellular bridge stability during cytokinesis.
   
    0.521
CG11396
RE19263p; Endopeptidase activity. It is involved in the biological process described with: Golgi vesicle transport.
   
  
 0.513
Dscam1
Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity.
   
 
 0.508
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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