STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tal-1ATarsal-less 1A (tal-1A) encodes one of four open reading frames within the tal polycistronic transcription unit. The encoded peptide controls the post-transcriptional activation of the product of ovo, which in turn regulates Notch signalling and F-actin organization. (11 aa)    
Predicted Functional Partners:
tal-2A
Tarsal-less 2A (tal-2A) encodes one of four open reading frames within the tal polycistronic transcription unit. The encoded peptide controls the post-transcriptional activation of the product of ovo, which in turn regulates Notch signalling and F-actin organization.
      
 0.914
tal-3A
Tarsal-less 3A (tal-3A) encodes one of four open reading frames within the tal polycistronic transcription unit. The encoded peptide controls the post-transcriptional activation of the product of ovo, which in turn regulates Notch signalling and F-actin organization.
      
 0.914
CG11226
AT16729p.
      
 0.792
whe
What else, isoform A.
      
 0.680
Kaz1-ORFB
KAZ1-type serine protease inhibitor-like protein type epsilon.
      
 0.672
CG12717
FI06413p; SUMO-specific isopeptidase activity; SUMO-specific endopeptidase activity. It is involved in the biological process described with: dendritic spine morphogenesis; central nervous system projection neuron axonogenesis; protein desumoylation.
      
 0.658
smp-30
Senescence marker protein-30 (smp-30) encodes a calcium binding protein involved in calcium homeostasis regulation. It negatively influences cell proliferation and tissue size, possibly through the insulin pathway. It contributes to body size variation, diapause and thermal stress resistance.
      
 0.493
tal-AA
Peptide tarsal-less AA; One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes. Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation. Promotes the post- translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development. This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to sv [...]
      
 0.491
Pka-C3
cAMP-dependent protein kinase catalytic subunit 3; Does not have an essential role in development. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
      
 0.430
wds
Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'.
      
 0.430
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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