| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG33784 | CG42326 | FBpp0091043 | FBpp0308444 | Uncharacterized protein. | Uncharacterized protein, isoform E; It is involved in the biological process described with: multicellular organism reproduction. | 0.913 |
| CG33784 | Spn42Dd | FBpp0091043 | FBpp0289586 | Uncharacterized protein. | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | 0.609 |
| CG42304 | Spn42Dd | FBpp0288962 | FBpp0289586 | LD20870p; DNA binding; nucleosome binding. | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | 0.663 |
| CG42326 | CG33784 | FBpp0308444 | FBpp0091043 | Uncharacterized protein, isoform E; It is involved in the biological process described with: multicellular organism reproduction. | Uncharacterized protein. | 0.913 |
| CG42326 | Spn42Dd | FBpp0308444 | FBpp0289586 | Uncharacterized protein, isoform E; It is involved in the biological process described with: multicellular organism reproduction. | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | 0.610 |
| SPE | Spn42Dd | FBpp0083832 | FBpp0289586 | Spaetzle-processing enzyme heavy chain; Endopeptidase which plays a key role in innate immunity by cleaving Tl ligand spz and thereby activating the Toll pathway in response to fungal and Gram-positive bacterial infections. Acts downstream of pathogen recognition receptors PGRP-SA and GNBP1 and protease grass in response to Gram-positive bacterial infection. Acts downstream of protease psh in response to fungal infection. Belongs to the peptidase S1 family. CLIP subfamily. | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | 0.591 |
| SPE | Spn43Ab | FBpp0083832 | FBpp0099762 | Spaetzle-processing enzyme heavy chain; Endopeptidase which plays a key role in innate immunity by cleaving Tl ligand spz and thereby activating the Toll pathway in response to fungal and Gram-positive bacterial infections. Acts downstream of pathogen recognition receptors PGRP-SA and GNBP1 and protease grass in response to Gram-positive bacterial infection. Acts downstream of protease psh in response to fungal infection. Belongs to the peptidase S1 family. CLIP subfamily. | Serpin 43Ab; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; multicellular organism reproduction; Belongs to the serpin family. | 0.421 |
| SPE | nec | FBpp0083832 | FBpp0088123 | Spaetzle-processing enzyme heavy chain; Endopeptidase which plays a key role in innate immunity by cleaving Tl ligand spz and thereby activating the Toll pathway in response to fungal and Gram-positive bacterial infections. Acts downstream of pathogen recognition receptors PGRP-SA and GNBP1 and protease grass in response to Gram-positive bacterial infection. Acts downstream of protease psh in response to fungal infection. Belongs to the peptidase S1 family. CLIP subfamily. | GH10112p; Necrotic (nec) encodes a hemolymphatic Serpin that negatively regulates a serine protease involved in the immune activation of the Toll pathway. It is thought to function at the level or upstream of the serine protease encoded by psh. | 0.868 |
| Sbat | Spn42Dd | FBpp0304730 | FBpp0289586 | Sabbat, isoform A. | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | 0.602 |
| Sbat | Vlet | FBpp0304730 | FBpp0073378 | Sabbat, isoform A. | Valette, isoform B. | 0.928 |
| Spn28Dc | Spn42Dd | FBpp0079171 | FBpp0289586 | Serine protease inhibitor 28Dc; Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and p [...] | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | 0.591 |
| Spn28Dc | Spn43Ab | FBpp0079171 | FBpp0099762 | Serine protease inhibitor 28Dc; Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and p [...] | Serpin 43Ab; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; multicellular organism reproduction; Belongs to the serpin family. | 0.612 |
| Spn28Dc | Spn77Ba | FBpp0079171 | FBpp0311802 | Serine protease inhibitor 28Dc; Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and p [...] | Serine protease inhibitor 77Ba; Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection. Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade ; Belongs to the serpin family. | 0.777 |
| Spn28Dc | nec | FBpp0079171 | FBpp0088123 | Serine protease inhibitor 28Dc; Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and p [...] | GH10112p; Necrotic (nec) encodes a hemolymphatic Serpin that negatively regulates a serine protease involved in the immune activation of the Toll pathway. It is thought to function at the level or upstream of the serine protease encoded by psh. | 0.699 |
| Spn42Dd | CG33784 | FBpp0289586 | FBpp0091043 | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | Uncharacterized protein. | 0.609 |
| Spn42Dd | CG42304 | FBpp0289586 | FBpp0288962 | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | LD20870p; DNA binding; nucleosome binding. | 0.663 |
| Spn42Dd | CG42326 | FBpp0289586 | FBpp0308444 | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | Uncharacterized protein, isoform E; It is involved in the biological process described with: multicellular organism reproduction. | 0.610 |
| Spn42Dd | SPE | FBpp0289586 | FBpp0083832 | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | Spaetzle-processing enzyme heavy chain; Endopeptidase which plays a key role in innate immunity by cleaving Tl ligand spz and thereby activating the Toll pathway in response to fungal and Gram-positive bacterial infections. Acts downstream of pathogen recognition receptors PGRP-SA and GNBP1 and protease grass in response to Gram-positive bacterial infection. Acts downstream of protease psh in response to fungal infection. Belongs to the peptidase S1 family. CLIP subfamily. | 0.591 |
| Spn42Dd | Sbat | FBpp0289586 | FBpp0304730 | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | Sabbat, isoform A. | 0.602 |
| Spn42Dd | Spn28Dc | FBpp0289586 | FBpp0079171 | Serine protease inhibitor 42Dd; Serine protease inhibitor with activity toward trypsin. Involved in innate immunity to fungal infection by negatively regulating the Toll signaling pathway and suppressing the expression of the antifungal peptide drosomycin. Acts upstream of SPE and grass, and downstream of the fungal cell wall pattern recognition receptor GNBP3. May function specifically in the GNBP3-dependent beta-1,3-glucan branch of the Toll pathway. | Serine protease inhibitor 28Dc; Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and p [...] | 0.591 |