STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TTLL4ATubulin tyrosine ligase-like 4A, isoform D; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity; tubulin binding. It is involved in the biological process described with: protein polyglutamylation; microtubule cytoskeleton organization; protein polyglycylation; wound healing. (1071 aa)    
Predicted Functional Partners:
TTLL5
Tubulin tyrosine ligase-like 5, isoform A; Protein-glycine ligase activity; tubulin-glutamic acid ligase activity; ATP binding; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; C-terminal protein amino acid modification; protein polyglycylation; protein polyglutamylation.
   
  
0.596
DUBAI
Deubiquitinating apoptotic inhibitor, isoform A; Cysteine-type endopeptidase activity; protein binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; negative regulation of apoptotic process; negative regulation of proteolysis involved in cellular protein catabolic process; ubiquitin-dependent protein catabolic process.
      
 0.567
Dmtn
Dementin, isoform H; Dementin (Dmtn) encodes a protein that possesses an evolutionarily conserved interaction with members of the Amyloid beta A4 protein family. Co-expression of Dmtn rescues the effect of over-expressing human Amyloid beta A4 protein on development and behavior, and mutation of Dmtn causes aberrant processing of the product of Appl.
      
 0.546
CG16758
Uncharacterized protein, isoform H; Purine-nucleoside phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process.
      
 0.532
Tat
Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]
   
  
 0.511
TTLL6A
Tubulin tyrosine ligase-like 6A; Tubulin-glutamic acid ligase activity; protein-glycine ligase activity; ATP binding; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation.
  
  
0.498
TTLL1A
Tubulin tyrosine ligase-like 1A; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation.
  
  
0.497
SCaMC
Short Calcium-binding Mitochondrial Carrier (SCaMC) encodes a mitochondrial carrier family protein with calcium-binding motifs. SCaMC transcripts are strongly detected in the corpora allata, suggesting its potential role in juvenile hormone biosynthesis.
      
 0.497
TTLL1B
Tubulin tyrosine ligase-like 1B; Tubulin binding; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity. It is involved in the biological process described with: protein polyglutamylation; microtubule cytoskeleton organization; protein polyglycylation.
  
  
0.496
Fbl6
F-box and leucine-rich repeat protein 6, isoform A; SAM domain binding. It is involved in the biological process described with: positive regulation of ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of protein stability; ubiquitin-dependent protein catabolic process.
   
  
 0.496
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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