STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AceAcetylcholinesterase 16 kDa subunit; Acetylcholine esterase (Ace) encodes an enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine to acetate and choline, thus resetting the neurotransmission mechanism at neuromuscular junctions; Belongs to the type-B carboxylesterase/lipase family. (649 aa)    
Predicted Functional Partners:
CG4757
Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family.
  
 
0.920
CG2818
LD22655p; Glycerophosphocholine phosphodiesterase activity; starch binding. It is involved in the biological process described with: glycerophospholipid catabolic process.
     
 0.906
CG2201
RE24176p; Choline kinase activity; ethanolamine kinase activity. It is involved in the biological process described with: phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process.
     
 0.902
VAChT
Vesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family.
   
  
 0.796
Rdl
Gamma-aminobutyric acid receptor subunit beta; Resistant to dieldrin (Rdl) encodes a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior.
   
  
 0.740
NitFhit
Nitrilase and fragile histidine triad fusion protein (NitFhit) encodes a bis(5'-adenosyl)-triphosphatase involved in nucleobase-containing compound metabolism.
   
  
 0.662
Spt-I
Pyridoxal phosphate binding; serine C-palmitoyltransferase activity. It is involved in the biological process described with: positive regulation of sphingolipid biosynthetic process; ceramide biosynthetic process; sphingosine biosynthetic process.
      
 0.645
shps
AT01267p; Oxidoreductase activity. It is involved in the biological process described with: oxidation-reduction process.
   
  
 0.634
CG9701
LP05116p; Beta-glucosidase activity. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 1 family.
   
  
 0.615
Est-6
Esterase-6; Transferred from the ejaculatory bulbs of males to the female genitals upon copulation, plays an important role in the reproductive biology.
  
 
0.606
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.