STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG4622Zinc finger CCHC domain-containing protein 8 homolog; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short- lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. May be involved in pre- mRNA splicing. (553 aa)    
Predicted Functional Partners:
CG11454
RRM domain-containing protein; mRNA binding; single-stranded RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome.
    
 
 0.999
Mtr4
Mtr4 helicase (Mtr4) encodes an RNA helicase involved in the viral defense response.
   
 
 0.986
Trf4
RT01008p; Transcription factor binding; RNA polymerase III regulatory region DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: transcription by RNA polymerase II; RNA polymerase III preinitiation complex assembly.
   
  
 0.892
Zcchc7
Zinc finger CCHC-type containing 7; Nucleic acid binding; zinc ion binding. It is involved in the biological process described with: defense response to virus.
      
 0.861
cmb
Combover, isoform A; Combover (cmb) encodes an in vitro substrate of the product of Rho1 that physically interacts with the planar cell polarity (PCP) effector encoded by mwh. It contributes to PCP during wing hair formation.
    
 
 0.747
Rrp42
IP10364p; AU-rich element binding.
   
 
 0.725
Cbp20
Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs [...]
    
 
 0.705
Trf4-1
Non-canonical poly(A) RNA polymerase protein Trf4-1; Involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Polyadenylates RNA processing and degradation intermediates of snRNAs and mRNAs.
      
 0.676
Panx
Protein panoramix; Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons. Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts. Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing. In the ovaries, forms a complex with n [...]
   
    0.632
Spx
Spliceosomal protein on the X; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
      
 0.606
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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