STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dpr4Defective proboscis extension response 4; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (323 aa)    
Predicted Functional Partners:
DIP-eta
Dpr-interacting protein eta, isoform B; It is involved in the biological process described with: synapse organization.
  
 
0.973
DIP-theta
Dpr-interacting protein theta; It is involved in the biological process described with: synapse organization.
  
 
0.669
Octbeta2R
Octopamine receptor beta-2R; Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Essential for ovulation and fertilization. During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin- dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways. Positively regulates synaptic growth; an action that is antagonized by Octbeta1R.
  
 
 0.488
otk
Tyrosine-protein kinase-like otk; Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons; Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    
 
 0.476
DIP-iota
Dpr-interacting protein iota; It is involved in the biological process described with: synapse organization.
   
 
0.476
dpr12
Defective proboscis extension response 12, isoform C; It is involved in the biological process described with: sensory perception of chemical stimulus; synaptic target recognition; synapse organization.
  
  
0.423
AstC-R2
Allatostatin C receptor 2 (AstC-R2) encodes G-protein coupled receptor for the neuropeptide encoded by AstC.
   
 
 0.423
DIP-alpha
Dpr-interacting protein alpha, isoform A; It is involved in the biological process described with: synapse organization.
  
  
0.414
CkIIalpha
Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
      
 0.407
CG14331
Uncharacterized protein.
   
  
 0.401
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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