node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
JHDM2 | Kdm2 | FBpp0311387 | FBpp0307736 | JmjC domain-containing histone demethylase 2 (JHDM2) encodes an enzyme that catalyzes the removal of methyl groups from the lysine 9 of the product of His3, and thereby promotes an open chromatin structure. | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | 0.958 |
JHDM2 | Kdm4A | FBpp0311387 | FBpp0087961 | JmjC domain-containing histone demethylase 2 (JHDM2) encodes an enzyme that catalyzes the removal of methyl groups from the lysine 9 of the product of His3, and thereby promotes an open chromatin structure. | Lysine (K)-specific demethylase 4A (Kdm4A) encodes a histone lysine demethylase that catalyzes removal of methyl groups using alpha-ketoglutarate as a cofactor. It demethylates H3K36me3 and is implicated in the demethylation of H3K9me3 and H3K56me3. Its roles include transcription, DNA repair, and heterochromatin silencing. | 0.860 |
JHDM2 | Kdm4B | FBpp0311387 | FBpp0302636 | JmjC domain-containing histone demethylase 2 (JHDM2) encodes an enzyme that catalyzes the removal of methyl groups from the lysine 9 of the product of His3, and thereby promotes an open chromatin structure. | Probable lysine-specific demethylase 4B; Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). | 0.860 |
Kdm2 | JHDM2 | FBpp0307736 | FBpp0311387 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | JmjC domain-containing histone demethylase 2 (JHDM2) encodes an enzyme that catalyzes the removal of methyl groups from the lysine 9 of the product of His3, and thereby promotes an open chromatin structure. | 0.958 |
Kdm2 | Kdm4A | FBpp0307736 | FBpp0087961 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | Lysine (K)-specific demethylase 4A (Kdm4A) encodes a histone lysine demethylase that catalyzes removal of methyl groups using alpha-ketoglutarate as a cofactor. It demethylates H3K36me3 and is implicated in the demethylation of H3K9me3 and H3K56me3. Its roles include transcription, DNA repair, and heterochromatin silencing. | 0.938 |
Kdm2 | Kdm4B | FBpp0307736 | FBpp0302636 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | Probable lysine-specific demethylase 4B; Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). | 0.937 |
Kdm2 | Psc | FBpp0307736 | FBpp0311526 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | Polycomb group protein Psc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain e [...] | 0.987 |
Kdm2 | RAF2 | FBpp0307736 | FBpp0075145 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | RING-associated factor 2, isoform A; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. | 0.972 |
Kdm2 | RYBP | FBpp0307736 | FBpp0311610 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | Ring and YY1 Binding Protein (RYBP) encodes a ubiquitin interacting protein. It interacts with epigenetic regulators of the Polycomb and trithorax groups to control post-translational histone modifications. The product of RYBP is involved in regulation of the innate immune response and cell death/cell survival, and the control of morphogenesis. | 0.978 |
Kdm2 | Sce | FBpp0307736 | FBpp0084614 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | E3 ubiquitin-protein ligase RING1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG [...] | 0.997 |
Kdm2 | SkpA | FBpp0307736 | FBpp0099971 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | SKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication. | 0.928 |
Kdm2 | Su(z)2 | FBpp0307736 | FBpp0303463 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | Suppressor of zeste 2 (Su(z)2) encodes a protein that regulates gene expression by modifying epigenetic marks. The gene is related to Psc and was orginally identified due to its ability to suppress transvection at z. | 0.971 |
Kdm2 | l(3)73Ah | FBpp0307736 | FBpp0075071 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | Lethal (3) 73Ah, isoform A; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; zinc ion binding. It is involved in the biological process described with: histone H2A-K119 monoubiquitination; inactivation of X chromosome by genetic imprinting. | 0.953 |
Kdm4A | JHDM2 | FBpp0087961 | FBpp0311387 | Lysine (K)-specific demethylase 4A (Kdm4A) encodes a histone lysine demethylase that catalyzes removal of methyl groups using alpha-ketoglutarate as a cofactor. It demethylates H3K36me3 and is implicated in the demethylation of H3K9me3 and H3K56me3. Its roles include transcription, DNA repair, and heterochromatin silencing. | JmjC domain-containing histone demethylase 2 (JHDM2) encodes an enzyme that catalyzes the removal of methyl groups from the lysine 9 of the product of His3, and thereby promotes an open chromatin structure. | 0.860 |
Kdm4A | Kdm2 | FBpp0087961 | FBpp0307736 | Lysine (K)-specific demethylase 4A (Kdm4A) encodes a histone lysine demethylase that catalyzes removal of methyl groups using alpha-ketoglutarate as a cofactor. It demethylates H3K36me3 and is implicated in the demethylation of H3K9me3 and H3K56me3. Its roles include transcription, DNA repair, and heterochromatin silencing. | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | 0.938 |
Kdm4B | JHDM2 | FBpp0302636 | FBpp0311387 | Probable lysine-specific demethylase 4B; Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). | JmjC domain-containing histone demethylase 2 (JHDM2) encodes an enzyme that catalyzes the removal of methyl groups from the lysine 9 of the product of His3, and thereby promotes an open chromatin structure. | 0.860 |
Kdm4B | Kdm2 | FBpp0302636 | FBpp0307736 | Probable lysine-specific demethylase 4B; Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | 0.937 |
Psc | Kdm2 | FBpp0311526 | FBpp0307736 | Polycomb group protein Psc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain e [...] | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. | 0.987 |
Psc | RAF2 | FBpp0311526 | FBpp0075145 | Polycomb group protein Psc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain e [...] | RING-associated factor 2, isoform A; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. | 0.857 |
Psc | RYBP | FBpp0311526 | FBpp0311610 | Polycomb group protein Psc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain e [...] | Ring and YY1 Binding Protein (RYBP) encodes a ubiquitin interacting protein. It interacts with epigenetic regulators of the Polycomb and trithorax groups to control post-translational histone modifications. The product of RYBP is involved in regulation of the innate immune response and cell death/cell survival, and the control of morphogenesis. | 0.925 |