STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG7166IP11255p; Axon guidance receptor activity. It is involved in the biological process described with: synapse organization; homophilic cell adhesion via plasma membrane adhesion molecules. (467 aa)    
Predicted Functional Partners:
wrapper
GH03113p; Wrapper (wrapper) encodes a protein involved in axon ensheathment and glial apoptosis.
  
  
0.561
AP-1-2beta
Adaptor Protein complex 1/2, beta subunit (AP-1-2beta) encodes a clathrin adaptor involved in vesicle trafficking and autophagy regulation.
   
  0.539
AP-2sigma
Adaptor Protein complex 2, sigma subunit (AP-2sigma) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization.
    
  0.532
AP-2mu
Adaptor Protein complex 2, mu subunit (AP-2mu) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization.
    
  0.532
Egfr
Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...]
    
  0.531
scb
Integrin alpha-PS3 heavy chain; Integrin alpha-PS3/beta-PS is a receptor for laminin. Also binds to wb. Important during embryogenesis for the development of the trachea, dorsal vessel and salivary gland, as well as for dorsal closure. Required for short-term memory processes. Minor involvement in the establishment of the oocyte anterior-posterior length. Plays a role in timely border cell migration during oogenesis, probably mediated by JNK signaling. Integrin alpha-PS3/Itgbn is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic [...]
    
  0.531
ItgaPS4
Integrin alpha-PS4; Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length.
    
  0.531
if
Integrin alpha-PS2 heavy chain; Inflated (if) encodes one of five fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as those encoded by Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers.
    
  0.531
ItgaPS5
Integrin alpha-PS5; Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length.
    
  0.531
Ank
Ankyrin, isoform B; Ankyrin (Ank) encodes protein that is recruited to the plasma membrane by its association with the product of beta-Spec. It also binds to the adhesion protein encoded by Nrg leading to accumulation of the products of Ank and beta-Spec at sites of cell-cell adhesion.
    
  0.530
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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