node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG11414 | CG46434 | FBpp0072214 | FBpp0423326 | FI04483p; Zinc ion binding; ubiquitin protein ligase activity; RNA binding. It is involved in the biological process described with: mitotic cell cycle. | Uncharacterized protein, isoform A. | 0.505 |
CG11414 | Clbn | FBpp0072214 | FBpp0290492 | FI04483p; Zinc ion binding; ubiquitin protein ligase activity; RNA binding. It is involved in the biological process described with: mitotic cell cycle. | Nuclear export mediator factor NEMF homolog; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Clbn/NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Clbn/NEMF is important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. | 0.854 |
CG11414 | Ltn1 | FBpp0072214 | FBpp0074742 | FI04483p; Zinc ion binding; ubiquitin protein ligase activity; RNA binding. It is involved in the biological process described with: mitotic cell cycle. | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to TER94/VCP recruitment for extraction and degradation of the incomplete translation product (By similarity). Belongs to the LTN1 family. | 0.678 |
CG11414 | Nulp1 | FBpp0072214 | FBpp0306682 | FI04483p; Zinc ion binding; ubiquitin protein ligase activity; RNA binding. It is involved in the biological process described with: mitotic cell cycle. | Nuclear localized protein 1, isoform A; DNA-binding transcription factor activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; positive regulation of canonical Wnt signaling pathway. | 0.877 |
CG11414 | pelo | FBpp0072214 | FBpp0079444 | FI04483p; Zinc ion binding; ubiquitin protein ligase activity; RNA binding. It is involved in the biological process described with: mitotic cell cycle. | Protein pelota; Required prior to the first meiotic division for spindle formation and nuclear envelope breakdown during spermatogenesis. It is also required for normal eye patterning and for mitotic divisions in the ovary. Required for ovarian germ line stem cell self-renewal. May play a role in regulating translation. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). | 0.591 |
CG46434 | CG11414 | FBpp0423326 | FBpp0072214 | Uncharacterized protein, isoform A. | FI04483p; Zinc ion binding; ubiquitin protein ligase activity; RNA binding. It is involved in the biological process described with: mitotic cell cycle. | 0.505 |
CG46434 | Clbn | FBpp0423326 | FBpp0290492 | Uncharacterized protein, isoform A. | Nuclear export mediator factor NEMF homolog; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Clbn/NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Clbn/NEMF is important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. | 0.879 |
CG46434 | Nulp1 | FBpp0423326 | FBpp0306682 | Uncharacterized protein, isoform A. | Nuclear localized protein 1, isoform A; DNA-binding transcription factor activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; positive regulation of canonical Wnt signaling pathway. | 0.616 |
CG46434 | RpL11 | FBpp0423326 | FBpp0309436 | Uncharacterized protein, isoform A. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.604 |
CG46434 | RpL23 | FBpp0423326 | FBpp0071808 | Uncharacterized protein, isoform A. | 60S ribosomal protein L23; Large ribosomal subunit rRNA binding; structural constituent of ribosome; myosin binding. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uL14 family. | 0.535 |
CG46434 | RpL23A | FBpp0423326 | FBpp0423205 | Uncharacterized protein, isoform A. | Ribosomal protein L23A (RpL23A) encodes an essential ribosomal RNA binding protein of the large ribosomal subunit involved in protein synthesis; Belongs to the universal ribosomal protein uL23 family. | 0.594 |
CG46434 | RpL35 | FBpp0423326 | FBpp0070767 | Uncharacterized protein, isoform A. | Ribosomal protein L35, isoform A; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); translation. | 0.538 |
CG46434 | RpL5 | FBpp0423326 | FBpp0311121 | Uncharacterized protein, isoform A. | 60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.543 |
Clbn | CG11414 | FBpp0290492 | FBpp0072214 | Nuclear export mediator factor NEMF homolog; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Clbn/NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Clbn/NEMF is important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. | FI04483p; Zinc ion binding; ubiquitin protein ligase activity; RNA binding. It is involved in the biological process described with: mitotic cell cycle. | 0.854 |
Clbn | CG46434 | FBpp0290492 | FBpp0423326 | Nuclear export mediator factor NEMF homolog; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Clbn/NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Clbn/NEMF is important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. | Uncharacterized protein, isoform A. | 0.879 |
Clbn | Ltn1 | FBpp0290492 | FBpp0074742 | Nuclear export mediator factor NEMF homolog; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Clbn/NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Clbn/NEMF is important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to TER94/VCP recruitment for extraction and degradation of the incomplete translation product (By similarity). Belongs to the LTN1 family. | 0.982 |
Clbn | Nulp1 | FBpp0290492 | FBpp0306682 | Nuclear export mediator factor NEMF homolog; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Clbn/NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Clbn/NEMF is important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. | Nuclear localized protein 1, isoform A; DNA-binding transcription factor activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; positive regulation of canonical Wnt signaling pathway. | 0.956 |
Clbn | RpL11 | FBpp0290492 | FBpp0309436 | Nuclear export mediator factor NEMF homolog; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Clbn/NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Clbn/NEMF is important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.894 |
Clbn | RpL23 | FBpp0290492 | FBpp0071808 | Nuclear export mediator factor NEMF homolog; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Clbn/NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Clbn/NEMF is important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. | 60S ribosomal protein L23; Large ribosomal subunit rRNA binding; structural constituent of ribosome; myosin binding. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uL14 family. | 0.888 |
Clbn | RpL23A | FBpp0290492 | FBpp0423205 | Nuclear export mediator factor NEMF homolog; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Clbn/NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Clbn/NEMF is important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. | Ribosomal protein L23A (RpL23A) encodes an essential ribosomal RNA binding protein of the large ribosomal subunit involved in protein synthesis; Belongs to the universal ribosomal protein uL23 family. | 0.884 |