node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arl6IP1 | ReepA | FBpp0082786 | FBpp0291910 | ARL-6-interacting protein 1 homolog; It is involved in the biological process described with: endoplasmic reticulum tubular network membrane organization. | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | 0.912 |
Arl6IP1 | ReepB | FBpp0082786 | FBpp0291641 | ARL-6-interacting protein 1 homolog; It is involved in the biological process described with: endoplasmic reticulum tubular network membrane organization. | Receptor expression-enhancing protein; It is involved in the biological process described with: regulation of intracellular transport; endoplasmic reticulum tubular network organization; endoplasmic reticulum organization. | 0.679 |
Arl6IP1 | Rtnl1 | FBpp0082786 | FBpp0290753 | ARL-6-interacting protein 1 homolog; It is involved in the biological process described with: endoplasmic reticulum tubular network membrane organization. | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | 0.718 |
Arl6IP1 | Sec61alpha | FBpp0082786 | FBpp0311774 | ARL-6-interacting protein 1 homolog; It is involved in the biological process described with: endoplasmic reticulum tubular network membrane organization. | Sec61 alpha subunit (Sec61alpha) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel. | 0.977 |
Arl6IP1 | atl | FBpp0082786 | FBpp0084037 | ARL-6-interacting protein 1 homolog; It is involved in the biological process described with: endoplasmic reticulum tubular network membrane organization. | Atlastin; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions. | 0.573 |
Arl6IP1 | spas | FBpp0082786 | FBpp0083918 | ARL-6-interacting protein 1 homolog; It is involved in the biological process described with: endoplasmic reticulum tubular network membrane organization. | Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. | 0.623 |
Pu | Rtnl1 | FBpp0071507 | FBpp0290753 | GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation. | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | 0.994 |
Pu | Vta1 | FBpp0071507 | FBpp0072691 | GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation. | Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport via multivesicular body sorting pathway. | 0.994 |
ReepA | Arl6IP1 | FBpp0291910 | FBpp0082786 | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | ARL-6-interacting protein 1 homolog; It is involved in the biological process described with: endoplasmic reticulum tubular network membrane organization. | 0.912 |
ReepA | Rtnl1 | FBpp0291910 | FBpp0290753 | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | 0.733 |
ReepA | atl | FBpp0291910 | FBpp0084037 | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | Atlastin; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions. | 0.958 |
ReepA | spas | FBpp0291910 | FBpp0083918 | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. | 0.922 |
ReepB | Arl6IP1 | FBpp0291641 | FBpp0082786 | Receptor expression-enhancing protein; It is involved in the biological process described with: regulation of intracellular transport; endoplasmic reticulum tubular network organization; endoplasmic reticulum organization. | ARL-6-interacting protein 1 homolog; It is involved in the biological process described with: endoplasmic reticulum tubular network membrane organization. | 0.679 |
ReepB | Rtnl1 | FBpp0291641 | FBpp0290753 | Receptor expression-enhancing protein; It is involved in the biological process described with: regulation of intracellular transport; endoplasmic reticulum tubular network organization; endoplasmic reticulum organization. | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | 0.848 |
Rtnl1 | Arl6IP1 | FBpp0290753 | FBpp0082786 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | ARL-6-interacting protein 1 homolog; It is involved in the biological process described with: endoplasmic reticulum tubular network membrane organization. | 0.718 |
Rtnl1 | Pu | FBpp0290753 | FBpp0071507 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation. | 0.994 |
Rtnl1 | ReepA | FBpp0290753 | FBpp0291910 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | 0.733 |
Rtnl1 | ReepB | FBpp0290753 | FBpp0291641 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | Receptor expression-enhancing protein; It is involved in the biological process described with: regulation of intracellular transport; endoplasmic reticulum tubular network organization; endoplasmic reticulum organization. | 0.848 |
Rtnl1 | Sec61alpha | FBpp0290753 | FBpp0311774 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | Sec61 alpha subunit (Sec61alpha) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel. | 0.655 |
Rtnl1 | Sec63 | FBpp0290753 | FBpp0076558 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation. | 0.785 |