node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMPKalpha | CG17698 | FBpp0070209 | FBpp0306043 | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. | Uncharacterized protein, isoform F; Protein serine/threonine kinase activity; calcium ion binding; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. | 0.953 |
AMPKalpha | Lkb1 | FBpp0070209 | FBpp0082280 | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. | Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. | 0.976 |
AMPKalpha | SNF4Agamma | FBpp0070209 | FBpp0290803 | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. | SNF4/AMP-activated protein kinase gamma subunit (SNF4Agamma) encodes a protein involved in lipid metabolism, autophagy and response to starvation. | 0.999 |
AMPKalpha | Tor | FBpp0070209 | FBpp0307598 | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] | 0.967 |
AMPKalpha | alc | FBpp0070209 | FBpp0087705 | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. | Alicorn, isoform A; Protein kinase binding. It is involved in the biological process described with: regulation of catalytic activity; maintenance of apical/basal cell polarity; neuron cellular homeostasis. | 0.999 |
AMPKalpha | foxo | FBpp0070209 | FBpp0293589 | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] | 0.970 |
AMPKalpha | raptor | FBpp0070209 | FBpp0311819 | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. | 0.979 |
CG17698 | AMPKalpha | FBpp0306043 | FBpp0070209 | Uncharacterized protein, isoform F; Protein serine/threonine kinase activity; calcium ion binding; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. | 0.953 |
CG17698 | Lkb1 | FBpp0306043 | FBpp0082280 | Uncharacterized protein, isoform F; Protein serine/threonine kinase activity; calcium ion binding; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. | Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. | 0.410 |
CG17698 | SNF4Agamma | FBpp0306043 | FBpp0290803 | Uncharacterized protein, isoform F; Protein serine/threonine kinase activity; calcium ion binding; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. | SNF4/AMP-activated protein kinase gamma subunit (SNF4Agamma) encodes a protein involved in lipid metabolism, autophagy and response to starvation. | 0.851 |
CG17698 | alc | FBpp0306043 | FBpp0087705 | Uncharacterized protein, isoform F; Protein serine/threonine kinase activity; calcium ion binding; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. | Alicorn, isoform A; Protein kinase binding. It is involved in the biological process described with: regulation of catalytic activity; maintenance of apical/basal cell polarity; neuron cellular homeostasis. | 0.745 |
CG17698 | l(3)05822 | FBpp0306043 | FBpp0083016 | Uncharacterized protein, isoform F; Protein serine/threonine kinase activity; calcium ion binding; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. | Lethal (3) 05822, isoform A. | 0.509 |
CG17698 | trbl | FBpp0306043 | FBpp0077893 | Uncharacterized protein, isoform F; Protein serine/threonine kinase activity; calcium ion binding; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. | Tribbles; Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth. Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome. In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program. Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis a [...] | 0.509 |
Cbs | SNF4Agamma | FBpp0076938 | FBpp0290803 | Cystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response; Belongs to the cysteine synthase/cystathionine beta- synthase family. | SNF4/AMP-activated protein kinase gamma subunit (SNF4Agamma) encodes a protein involved in lipid metabolism, autophagy and response to starvation. | 0.857 |
Cbs | alc | FBpp0076938 | FBpp0087705 | Cystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Alicorn, isoform A; Protein kinase binding. It is involved in the biological process described with: regulation of catalytic activity; maintenance of apical/basal cell polarity; neuron cellular homeostasis. | 0.405 |
Lkb1 | AMPKalpha | FBpp0082280 | FBpp0070209 | Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. | AMP-activated protein kinase alpha subunit (AMPKalpha) encodes the alpha subunit of the AMP-activated protein kinase (AMPK) complex. In general AMPK helps cells conserve energy through inhibition of energy consuming processes (fatty acid synthesis, protein synthesis). AMPK is usually active when the TOR pathway is inhibited. | 0.976 |
Lkb1 | CG17698 | FBpp0082280 | FBpp0306043 | Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. | Uncharacterized protein, isoform F; Protein serine/threonine kinase activity; calcium ion binding; ATP binding. It is involved in the biological process described with: protein phosphorylation; intracellular signal transduction. | 0.410 |
Lkb1 | SNF4Agamma | FBpp0082280 | FBpp0290803 | Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. | SNF4/AMP-activated protein kinase gamma subunit (SNF4Agamma) encodes a protein involved in lipid metabolism, autophagy and response to starvation. | 0.984 |
Lkb1 | Tor | FBpp0082280 | FBpp0307598 | Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] | 0.426 |
Lkb1 | alc | FBpp0082280 | FBpp0087705 | Lkb1 kinase (Lkb1) encodes a serine/threonine kinase that plays a master role for activating the AMP-dependent protein kinase (AMPK) family kinases. It is a well-characterized tumor suppressor and regulates processes like cell polarity, metabolism, apoptosis, and cell growth. | Alicorn, isoform A; Protein kinase binding. It is involved in the biological process described with: regulation of catalytic activity; maintenance of apical/basal cell polarity; neuron cellular homeostasis. | 0.984 |