STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
lectin-46Cblectin-46Cb (lectin-46Cb) encodes a protein with homology to C-type lectins. It is produced in the male accessory gland and transferred to females during mating. In mated females, is required for the binding of product of SP to sperm, and for maintenance of long-term post-mating responses. (322 aa)    
Predicted Functional Partners:
CG9997
Uncharacterized protein, isoform A; CG9997 encodes a protein with homology to serine-type endopeptidases, but is not predicted to have catalytic activity due to mutations in its active site. It is produced in the male accessory gland and transferred to females during mating. In males, it is required for other seminal proteins to be transferred to mated females. In mated females, it is required for the binding of the product of SP to sperm and for the maintenance of long-term post-mating responses.
   
 
 0.941
CG17575
Uncharacterized protein, isoform B; CG17575 encodes a cysteine-rich secretory protein produced in the male accessory glands and transferred to females during mating. In mated females, it is required for the binding of the product of SP to sperm and for the consequent maintenance of long-term post-mating responses.
   
  
 0.930
Acp36DE
Accessory gland protein Acp36DE; Responsible for physiological and behavioral changes in mated female flies. Associates with sperm and localizes to specific regions of the female reproductive tract, including the sperm storage organs. It accelerates sperm accumulation into storage but does not mediate the entry of the first sperm into storage. Once sperm storage has initiated it seems to act as a guidance factor helping subsequent sperm move into storage, a corral concentrating sperm around the SSO entrances and/or a trigger for responses within the female that accelerate storage of sperm.
   
 
 0.925
antr
Antares, isoform B; It is involved in the biological process described with: negative regulation of female receptivity, post-mating; sperm storage; multicellular organism reproduction.
   
  
 0.909
Sems
Seminase (Sems) encodes a serine protease produced in male's accessory glands and transferred to females during mating. It is an essential component in the pathway for proteolytic processing of different seminal proteins. It cleaves the metalloprotease encoded by Semp1, which in turn also cleaves the seminal proteins encoded by Acp26Aa and Acp36DE. It is also required for sperm release from storage via regulation of the product of SP.
   
 
 0.902
SP
Accessory gland-specific peptide 70A; Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila. Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors. Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial pe [...]
   
  
 0.901
Acp29AB
Accessory gland protein 29AB (Acp29AB) encodes a predicted C-type lectin that is produced by the male accessory glands and transferred to females during mating. After transfer to mated females, the Acp29AB product is detected in sperm storage organs and in the hemolymph. It plays a role in retention of sperm in storage and sperm competition.
   
  
 0.883
Acp62F
Accessory gland protein Acp62F; Responsible for physiological and behavioral changes in mated female flies. May contribute to the toxicity of seminal fluid and the decreased life-span of mated females. May also affect neuromuscular events after mating concerning sperm storage and egg release.
   
  
 0.865
aqrs
Aquarius (aqrs) encodes a predicted serine protease produced by the male accessory glands and transferred to females during mating. It is required for the binding of the product of SP to sperm and for the transfer of the products of lectin-46Ca and lectin-46Cb to females during mating.
   
 
 0.865
Semp1
Seminal metalloprotease-1 (Semp1) encodes a metalloprotease that is produced by male accessory glands and transferred to females during mating. It is cleavage activated during mating, first by the product of Sems and then by auto-catalysis. The product of also cleaves at least two other seminal proteins, encoded by Acp26Aa and Acp36DE, in the mated female.
   
 
 0.853
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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