STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
PpnPapilin; Essential extracellular matrix (ECM) protein that influences cell rearrangements. May act by modulating metalloproteinases action during organogenesis. Able to non-competitively inhibit procollagen N- proteinase, an ADAMTS metalloproteinase; Belongs to the papilin family. (2898 aa)    
Predicted Functional Partners:
Glt
Glutactin (Glt) encodes a secreted protein that belongs to the family of cholinesterase/carboxylesterase-like proteins but lacks the catalytically active residues. It forms part of the basement membrane and regulates axonal outgrowth.
   
  
 0.735
vkg
Viking, isoform A; Viking (vkg) encodes a subunit of Collagen IV and a major component of basement membranes. It is secreted by haemocytes and fat body cells and is required for the normal morphogenesis of many tissues. It also contributes to TGF-beta signalling in the early embryo and the developing Malpighian tubules.
   
  
 0.678
Tig
Tiggrin (Tig) is an extracellular matrix protein and integrin ligand that accumulates at the embryonic and larval muscle attachment site. It is also found as a component of the hemolymph clot.
   
 
 0.672
LanA
Laminin subunit alpha; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Activates presynaptic signaling involving integrin alpha-PS3/beta-nu and Fak to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with integrin alpha-PS3/beta-nu, glutamate receptor-modulated NMJ growth.
   
  
 0.666
mspo
M-spondin, isoform A; It is involved in the biological process described with: cell adhesion; regulation of myoblast fusion.
   
 
 0.606
Hml
Hemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction.
   
 
 0.598
LanB1
LanB1 (LanB1) encodes a subunit of laminin, a heterotrimeric protein found in the extracellular matrix (ECM) and a major component of the basal lamina. Laminins interact with a variety of cell surface molecules such as integrin receptors and other secreted ECM components. It contributes to ECM organization, tissue adhesion, cell motility and developmental patterning.
   
  
 0.560
CG7702
LP06937p.
   
  
 0.542
SPARC
Secreted protein, acidic, cysteine-rich (SPARC) encodes a small calcium and growth factor-binding secreted glycoprotein that is enriched in basement membranes. During cell competition, it is expressed in "loser" cells so they can avoid apoptosis mediated by the products of fwe and azot.
   
  
 0.541
Ndg
Nidogen; Cell adhesion glycoprotein which is widely distributed in basement membranes. Involved in cell-extracellular matrix (ECM) interactions probably by connecting the laminin and collagen IV networks. Required for permeability and mechanical stability of basement membranes, and ECM dependent neural plasticity. Not involved in assembly of the embryonic basement membrane.
   
  
 0.535
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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