STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
ovoTranscriptional activator shavenbaby; Transcriptional regulator with essential functions in the germline and soma. Plays an essential role in regulating the formation of apical cell extensions such as denticles and aristae, and initiating cytoskeletal remodeling during epidermal differentiation. [Transcriptional activator shavenbaby]: Transcriptional activator which initiates trichome development and also promotes tarsal joint development. Has an essential somatic role regulating the tal-dependent formation of trichomes, and initiating cytoskeletal remodeling during epidermal different [...] (1351 aa)    
Predicted Functional Partners:
tal-AA
Peptide tarsal-less AA; One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes. Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation. Promotes the post- translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development. This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to sv [...]
      
 0.891
Ubr3
E3 ubiquitin-protein ligase Ubr3; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation. Binds to the E3 ubiquitin-protein ligase Diap1 and enhances its ubiquitination and anti-apoptotic functions. Essential during trichome development for the ubiquitination of the N-terminus of ovo isoform B (svb), converting it from a transcriptional inhibitor to an activator. Positively regulates a hh-signaling pathway which functions in photorecepto [...]
    
 
 0.878
CG14395
Uncharacterized protein, isoform B.
      
 0.835
sv
Shaven, isoform A; Shaven (sv) encodes a transcription factor and a member of the paired box family of genes. It is primarily involved in the terminal differentiation of specific cell types during the development of a variety of sensory organs, including the bristles and the eye.
      
 0.710
sha
Shavenoid, isoform B; Shavenoid (sha) encodes a novel protein that appears to promote trichome (hair) formation. sha mutations interact synergistically with mutations in fz/stan pathway genes.
   
  
 0.705
exd
Homeobox protein extradenticle; Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system.
   
  
 0.629
Osi24
Osiris 24.
      
 0.605
baf
Barrier-to-autointegration factor; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Functions are required in both M phase and interphase of the cell cycle. Belongs to the BAF family.
      
 0.604
dyl
Dusky-like, isoform A; Dusky-like (dyl) encodes a plasma membrane protein involved in actin filament organization. It is involved in apical constriction, cell-matrix adhesion and hair morphogenesis.
      
 0.603
wg
Protein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...]
    
 
 0.591
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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