STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uexUnextended, isoform E; Transmembrane transporter activity. It is involved in the biological process described with: cellular ion homeostasis. (834 aa)    
Predicted Functional Partners:
PRL-1
PRL-1 phosphatase (PRL-1) encodes a growth inhibitor that counteracts the function of the product of the Src42A oncogene.
    
 
 0.831
l(2)41Ab
Lethal (2) 41Ab, isoform A; It is involved in the biological process described with: cilium movement; axonemal dynein complex assembly.
   
  
 0.798
CG17883
RE60063p; GTPase activator activity; Rab GTPase binding. It is involved in the biological process described with: regulation of GTPase activity; endoplasmic reticulum to Golgi vesicle-mediated transport.
   
  
 0.693
CG17683
Probable cytosolic Fe-S cluster assembly factor CG17683; Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity); Belongs to the NARF family.
   
  
 0.673
bur
Burgundy, isoform B; Burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7.
  
  
 0.620
ClpP
ATP-dependent Clp protease proteolytic subunit; ATP-dependent peptidase activity; ATPase binding; serine-type endopeptidase activity. It is involved in the biological process described with: protein quality control for misfolded or incompletely synthesized proteins; proteolysis involved in cellular protein catabolic process; regulation of mitochondrial gene expression.
     
 0.572
Sam-S
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
  
  
 0.562
CG12547
RE33981p.
   
  
 0.556
Cbs
Cystathionine beta-synthase (Cbs) encodes an enzyme involved in endoplasmic reticulum stress response; Belongs to the cysteine synthase/cystathionine beta- synthase family.
     
 0.544
CG17684
Uncharacterized protein, isoform C; Serine-type peptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S9B family.
      
 0.531
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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