DNA polymerase delta catalytic subunit; As the catalytic component of the DNA polymerase delta complex, plays a crucial role in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair (By similarity). Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Required at the nucleus of rapidly dividing embryonic cells to activate genome replication during the earliest cell cycles. Likely to require the presence of accessory proteins Pol31 and Pol32 for full activity.

DNA polymerase zeta catalytic subunit; As the catalytic subunit of the DNA polymerase zeta complex, plays a crucial role in translesion DNA synthesis (TLS) and various DNA repair mechanisms. Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. During homologous recombination (HR) repair, has a overlapping role with the error-prone translesion polymerase eta to initiate repair synthesis which is completed by end joining or another polymerase that can bind and reinitiate synthesis. May participate in the Rrp1- dependent base excision repair (BER) pathway r [...]

DNA polymerase zeta processivity subunit; As the accessory component of the DNA polymerase zeta complex, involved in translesion DNA synthesis (TLS) and various DNA repair mechanisms. Promotes the apurinic/apyrimidinic (AP) endonuclease activity of Rrp1 and is therefore likely to be involved in the base excision repair (BER) pathway responsible for repair of DNA lesions. It does not appear to influence the synthesis activity of the catalytic component Dmpol-zeta.

DNA repair protein Rev1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). During homologous recombination (HR) repair of DNA double-strand breaks (DSBs) regulates the extent of repair synthesis. Possibly recruits the DNA polymerase zeta complex or another translesion polymerase to earl [...]

DNA polymerase alpha catalytic subunit; Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, an accessory subunit POLA2/p70 and two primase subunits, the catalytic subunit PRIM1/p49 and the regulatory subunit PRIM2/p58) is recruited to DNA at the replicative forks. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligome [...]

DNA polymerase epsilon catalytic subunit 1; Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication. Has a role in the G1-S transition and/or S-phase progression of the mitotic cycle and endocycle progression. Involved in DNA synthesis during DNA repair (By similarity). [...]

DNA primase small subunit; Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit DNApol-alpha180/DNApolA1, an accessory subunit DNApol-alpha73/DNApolA2 and two primase subunits, the catalytic subunit DNApol-alpha50/DNAprim1 and the regulatory subunit DNApol- alpha60/DNAprim2) is recruited to DNA at the replicative forks (By [...]

DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit DNApol- alpha180/DNApolA1, an accessory subunit DNApol-alpha73/DNApolA2 and two primase subunits, the catalytic subunit DNApol-alpha50/DNAprim1 and the regulatory subunit DNApol-alpha60/DNAprim2) is recruited to DNA at the replicative forks (B [...]

Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.