STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG34384Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). (1936 aa)    
Predicted Functional Partners:
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase activity; transferase activity, transferring acyl groups.
     
 0.907
Agpat4
Transferase activity, transferring acyl groups; 1-acylglycerol-3-phosphate O-acyltransferase activity.
     
 0.907
Pld
Phospholipase; Phosphatidylinositol binding; phospholipase D activity.
     
 0.906
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase activity. It is involved in the biological process described with: phosphatidic acid biosynthetic process; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
     
 0.904
sl
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Small wing (sl) encodes a phosphatidylinositol-specific phospholiase type C that is required as a general modulator for growth downstream of the insulin pathway, and interacts with the Ras-MAPK pathway.
     
 0.904
norpA
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...]
   
 
 0.904
Cds
Phosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...]
     
 0.904
Dgat2
Diacylglycerol O-acyltransferase activity; O-acyltransferase activity. It is involved in the biological process described with: lipid droplet organization; mesoderm development; lipid metabolic process; triglyceride biosynthetic process.
     
 0.903
CG1946
IP08359p; O-acyltransferase activity; diacylglycerol O-acyltransferase activity. It is involved in the biological process described with: triglyceride biosynthetic process; lipid metabolic process.
     
 0.903
Plc21C
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
     
 0.903
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.