node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dcr-2 | Pop1 | FBpp0086061 | FBpp0070748 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | 0.746 |
Dcr-2 | Pop5 | FBpp0086061 | FBpp0075046 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. | 0.721 |
Dcr-2 | Rpp21 | FBpp0086061 | FBpp0312373 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | Uncharacterized protein, isoform A; Ribonuclease P activity. It is involved in the biological process described with: tRNA processing; tRNA 5'-leader removal. | 0.720 |
Dcr-2 | Taf11 | FBpp0086061 | FBpp0079514 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | TBP-associated factor 11 (Taf11) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. It enhances RNA interference efficiency, organizing the assembly of the RISC loading complex. | 0.942 |
Dcr-2 | drosha | FBpp0086061 | FBpp0087926 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. | 0.988 |
Dcr-2 | mldr | FBpp0086061 | FBpp0293947 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | Mulder, isoform A; Mulder (mldr) encodes a protein involved in mitochondrial tRNA processing. | 0.903 |
Dcr-2 | r2d2 | FBpp0086061 | FBpp0079112 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | R2d2, isoform A; R2d2 (r2d2) encodes a double-stranded RNA-binding protein. It interacts with the product of Dcr-2 to form the core of RISC loading complex, which recruits duplex siRNA to the RISC. | 0.999 |
Dcr-2 | rswl | FBpp0086061 | FBpp0085875 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | Mitochondrial ribonuclease P protein 1 homolog; May function in mitochondrial tRNA maturation; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family. | 0.907 |
Dcr-2 | scu | FBpp0086061 | FBpp0074285 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | 3-hydroxyacyl-CoA dehydrogenase type-2; May function in mitochondrial tRNA maturation. Catalyzes the beta-oxidation at position 17 of androgens and estrogens, and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-beta-hydroxylated bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. Required for cell survival during embryonic development. May play a role in germline formation; Belongs to the short-chain dehydrogenases/reductases [...] | 0.900 |
Pop1 | Dcr-2 | FBpp0070748 | FBpp0086061 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | 0.746 |
Pop1 | Pop5 | FBpp0070748 | FBpp0075046 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. | 0.999 |
Pop1 | Rpp21 | FBpp0070748 | FBpp0312373 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | Uncharacterized protein, isoform A; Ribonuclease P activity. It is involved in the biological process described with: tRNA processing; tRNA 5'-leader removal. | 0.999 |
Pop1 | Taf11 | FBpp0070748 | FBpp0079514 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | TBP-associated factor 11 (Taf11) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. It enhances RNA interference efficiency, organizing the assembly of the RISC loading complex. | 0.724 |
Pop1 | drosha | FBpp0070748 | FBpp0087926 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. | 0.748 |
Pop1 | mldr | FBpp0070748 | FBpp0293947 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | Mulder, isoform A; Mulder (mldr) encodes a protein involved in mitochondrial tRNA processing. | 0.916 |
Pop1 | r2d2 | FBpp0070748 | FBpp0079112 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | R2d2, isoform A; R2d2 (r2d2) encodes a double-stranded RNA-binding protein. It interacts with the product of Dcr-2 to form the core of RISC loading complex, which recruits duplex siRNA to the RISC. | 0.739 |
Pop1 | rswl | FBpp0070748 | FBpp0085875 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | Mitochondrial ribonuclease P protein 1 homolog; May function in mitochondrial tRNA maturation; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family. | 0.735 |
Pop1 | scu | FBpp0070748 | FBpp0074285 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | 3-hydroxyacyl-CoA dehydrogenase type-2; May function in mitochondrial tRNA maturation. Catalyzes the beta-oxidation at position 17 of androgens and estrogens, and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-beta-hydroxylated bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. Required for cell survival during embryonic development. May play a role in germline formation; Belongs to the short-chain dehydrogenases/reductases [...] | 0.720 |
Pop5 | Dcr-2 | FBpp0075046 | FBpp0086061 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. | 0.721 |
Pop5 | Pop1 | FBpp0075046 | FBpp0070748 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. | 0.999 |