STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABCAATP binding cassette subfamily A, isoform B; ATPase activity; ATP binding; ATPase-coupled transmembrane transporter activity; lipid transporter activity. It is involved in the biological process described with: lipid transport; transmembrane transport. (1714 aa)    
Predicted Functional Partners:
ABCD
ATP-binding cassette sub-family D member; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation; Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
   
  
 0.974
CG10505
Uncharacterized protein; CG10505 encodes an ABC transporter whose expression is induced by excess copper, zinc, and cadmium. It is a target of the metal-responsive transcription factor encoded by MTF-1.
  
 
 0.699
CG31121
FI03229p; ATPase-coupled transmembrane transporter activity; ATP binding; ATPase activity. It is involved in the biological process described with: transmembrane transport.
      
 0.613
CG42815
GEO02653p1.
 
    
 0.549
Sur
ATP-binding cassette sub-family C member Sur; May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP- sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress.
  
 
 0.534
Ced-12
Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization.
   
  
 0.497
ced-6
PTB domain-containing adapter protein ced-6; Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth.
      
 0.491
Eato
Engulfment ABC transporter in the ovary, isoform B; Lipid transporter activity; ATP binding; ATPase-coupled transmembrane transporter activity; ATPase activity. It is involved in the biological process described with: lipid transport; transmembrane transport.
  
 
 
0.487
CG1703
LD04461p; ATP binding; ATPase activity.
      
 0.486
Pmp70
Peroxisomal membrane protein 70 kDa, isoform A; Protein homodimerization activity; ATPase-coupled transmembrane transporter activity; ATP binding; ATPase activity. It is involved in the biological process described with: long-chain fatty acid import into peroxisome.
   
  
 0.466
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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