Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP-1-2beta | ced-6 | FBpp0074558 | FBpp0297720 | Adaptor Protein complex 1/2, beta subunit (AP-1-2beta) encodes a clathrin adaptor involved in vesicle trafficking and autophagy regulation. | PTB domain-containing adapter protein ced-6; Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth. | 0.676 |
| Ced-12 | Crk | FBpp0079912 | FBpp0088182 | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | Adapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family. | 0.991 |
| Ced-12 | NimC4 | FBpp0079912 | FBpp0080169 | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | Nimrod C4 (NimC4) encodes a transmembrane phagocytic receptor that binds phosphatidylserine exposed on apoptotic cells. Its roles include recognition and engulfment of apoptotic cells during development. | 0.609 |
| Ced-12 | Rab5 | FBpp0079912 | FBpp0077473 | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. | 0.451 |
| Ced-12 | Shark | FBpp0079912 | FBpp0086382 | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | Tyrosine-protein kinase Shark; Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system. Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity [...] | 0.618 |
| Ced-12 | Unc-76 | FBpp0079912 | FBpp0305896 | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | Unc-76, isoform A; Unc-76 (Unc-76) encodes a kinesin binding protein involved in axo-dendritic transport. | 0.579 |
| Ced-12 | ced-6 | FBpp0079912 | FBpp0297720 | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | PTB domain-containing adapter protein ced-6; Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth. | 0.966 |
| Ced-12 | drpr | FBpp0079912 | FBpp0306204 | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | Protein draper; Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria. Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis. Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis. Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells. Required for the pha [...] | 0.938 |
| Ced-12 | mbc | FBpp0079912 | FBpp0293271 | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | Myoblast city (mbc) encodes an unconventional bipartite GEF that, in combination with the product of Ced-12, activates the monomeric GTPase encoded by Rac1. It contributes to myoblast fusion, border cell migration and dorsal closure; Belongs to the DOCK family. | 0.999 |
| Ced-12 | mtm | FBpp0079912 | FBpp0311457 | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | Myotubularin, isoform A; Myotubularin (mtm) encodes a phosphatidylinositol-3-phosphatase that, together with the products of Sbf and Rab21, regulates macrophage protrusion formation. It is involved in cortical actin cytoskeleton organization, chromosome segregation and endocytic recycling. | 0.593 |
| Crk | Ced-12 | FBpp0088182 | FBpp0079912 | Adapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family. | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | 0.991 |
| Crk | ced-6 | FBpp0088182 | FBpp0297720 | Adapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family. | PTB domain-containing adapter protein ced-6; Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth. | 0.861 |
| Crk | drpr | FBpp0088182 | FBpp0306204 | Adapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family. | Protein draper; Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria. Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis. Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis. Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells. Required for the pha [...] | 0.823 |
| Crk | mbc | FBpp0088182 | FBpp0293271 | Adapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family. | Myoblast city (mbc) encodes an unconventional bipartite GEF that, in combination with the product of Ced-12, activates the monomeric GTPase encoded by Rac1. It contributes to myoblast fusion, border cell migration and dorsal closure; Belongs to the DOCK family. | 0.999 |
| NimC4 | Ced-12 | FBpp0080169 | FBpp0079912 | Nimrod C4 (NimC4) encodes a transmembrane phagocytic receptor that binds phosphatidylserine exposed on apoptotic cells. Its roles include recognition and engulfment of apoptotic cells during development. | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | 0.609 |
| NimC4 | Shark | FBpp0080169 | FBpp0086382 | Nimrod C4 (NimC4) encodes a transmembrane phagocytic receptor that binds phosphatidylserine exposed on apoptotic cells. Its roles include recognition and engulfment of apoptotic cells during development. | Tyrosine-protein kinase Shark; Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system. Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity [...] | 0.446 |
| NimC4 | ced-6 | FBpp0080169 | FBpp0297720 | Nimrod C4 (NimC4) encodes a transmembrane phagocytic receptor that binds phosphatidylserine exposed on apoptotic cells. Its roles include recognition and engulfment of apoptotic cells during development. | PTB domain-containing adapter protein ced-6; Plays a role in axon pruning in larval mushroom body neurons during metamorphosis. Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches. Involved in Drpr-mediated phagocytosis of apoptotic cells. Required for bacterial phagocytosis. During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth. | 0.696 |
| NimC4 | drpr | FBpp0080169 | FBpp0306204 | Nimrod C4 (NimC4) encodes a transmembrane phagocytic receptor that binds phosphatidylserine exposed on apoptotic cells. Its roles include recognition and engulfment of apoptotic cells during development. | Protein draper; Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria. Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis. Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis. Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells. Required for the pha [...] | 0.415 |
| Rab5 | Ced-12 | FBpp0077473 | FBpp0079912 | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. | Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. | 0.451 |
| Rab5 | Unc-76 | FBpp0077473 | FBpp0305896 | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. | Unc-76, isoform A; Unc-76 (Unc-76) encodes a kinesin binding protein involved in axo-dendritic transport. | 0.424 |
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