STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MtnDMetallothionein-4; Metallothionein D (MtnD) encodes a member of the Metallothionein family whose transcription is strongly inducible by copper and cadmium ions. Its induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family. (44 aa)    
Predicted Functional Partners:
MtnE
Metallothionein E (MtnE) encodes one of the five metallothioneins. They are metal-binding polypeptides that coordinate both physiological and xenobiotic metal ions, either for homeostasis or detoxification purposes. The product of MtnE shows the least specificity towards binding metal ions.
   
  
 0.918
MtnA
Metallothionein-1; Metallothionein A (MtnA) encodes a member of the Metallothionein family whose transcript level is higher than that of the other four Drosophila metallothioneins. Transcription is strongly induced by copper and cadmium ions and this induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family.
      
 0.838
MTF-1
Metal response element-binding Transcription Factor-1 (MTF-1) encodes a zinc finger protein that primarily controls the homeostasis of physiological trace metals, such as zinc and copper, and the detoxification of non-essential, toxic heavy metals, such as cadmium, mercury, and silver. It activates a number of genes in response to heavy metal load but also induces transcription of the copper importer encoded by Ctr1B upon copper depletion. Variations in the DNA binding site can affect its response to a specific metal.
   
  
 0.836
CG34136
HDC03535.
   
  
 0.658
mat
Uncharacterized protein.
   
  
 0.614
CG13215
GEO11546p1.
      
 0.495
LManIV
Alpha-mannosidase; Carbohydrate binding; alpha-mannosidase activity. It is involved in the biological process described with: protein deglycosylation; mannose metabolic process.
   
  
 0.494
CG43061
Uncharacterized protein; It is involved in the biological process described with: pathogenesis.
      
 0.491
CG14820
RE62864p; Metallocarboxypeptidase activity; zinc ion binding. It is involved in the biological process described with: proteolysis.
      
 0.489
Ctr1B
Copper transporter 1B (Ctr1B) encodes a protein that ensures copper uptake in the intestine. Ctr1B transcription is upregulated under conditions of copper depletion via the metal-responsive transcription factor encoded by MTF-1.
      
 0.488
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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