STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hydr2Abhydrolase domain-containing protein 2; Alpha/beta hydrolase2 (Hydr2) encodes a lipase involved in lipid metabolism; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. (398 aa)    
Predicted Functional Partners:
CG3984
Uncharacterized protein.
      
 0.668
CG6650
LD24362p; ADP-specific glucokinase activity. It is involved in the biological process described with: carbohydrate metabolic process.
   
  
 0.556
smp-30
Senescence marker protein-30 (smp-30) encodes a calcium binding protein involved in calcium homeostasis regulation. It negatively influences cell proliferation and tissue size, possibly through the insulin pathway. It contributes to body size variation, diapause and thermal stress resistance.
      
 0.532
SPARC
Secreted protein, acidic, cysteine-rich (SPARC) encodes a small calcium and growth factor-binding secreted glycoprotein that is enriched in basement membranes. During cell competition, it is expressed in "loser" cells so they can avoid apoptosis mediated by the products of fwe and azot.
      
 0.523
Fdh
Alcohol dehydrogenase class-3; Formaldehyde dehydrogenase (Fdh) encodes a medium-chain alcohol dehydrogenase. This enzyme also functions as S-nitrosoglutathione reductase during the nitric oxide metabolism, contributing to visual memory.
  
  
 0.490
Gpdh1
Glycerol-3-phosphate dehydrogenase 1 (Gpdh1) encodes a glycerol-3-phosphate dehydrogenase that catalyzes the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate. It is involved in triglyceride metabolism, response to hyperoxia and flight behavior.
  
  
 0.484
nes
Lysophospholipid acyltransferase 5; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). May also catalyze the conversion of lysophosphatidylethanolamine (1-acyl-2-hydroxy-sn-glycero-3- phosphoethanolamine or LPE) to phosphatidylethanolamine (1,2-diacyl-sn- glycero-3-phosphoethanolamine or PE) (LPEAT activity), as well as the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3- phospho-L-serine or LPS) to phosphatidylser [...]
   
  
 0.477
Cyp4d21
Probable cytochrome P450 4d21; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
   
  
 0.462
CG7058
GH01369p; Ubiquitin protein ligase binding. It is involved in the biological process described with: regulation of proteolysis; ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process.
      
 0.430
Glut4EF
Glucose transporter 4 enhancer factor (Glut4EF) encodes a transcription factor important for developmental patterning and morphogenesis events.
   
  
 0.425
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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