STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RhoGAP102ARho GTPase activating protein at 102A, isoform D; GTPase activator activity. It is involved in the biological process described with: signal transduction; positive regulation of GTPase activity. (1256 aa)    
Predicted Functional Partners:
asp
Protein abnormal spindle; Required to maintain the structure of the centrosomal microtubule organizing center (MTOC) during mitosis. May have a preferential role in regulating neurogenesis. Required for germ cell mitosis and oocyte differentiation.
   
 
 0.869
Mps1
Monopolar spindle 1, isoform B; Monopolar spindle 1 (Mps1) encodes a conserved protein kinase that is associated with kinetochores and is required for the mitotic and meiotic spindle assembly checkpoints.
   
    0.857
Klp61F
Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...]
   
  
 0.778
CG32318
RT07324p; ATP-dependent microtubule motor activity, plus-end-directed; microtubule motor activity; ATP binding; microtubule binding. It is involved in the biological process described with: microtubule-based movement; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
  
 0.778
Sse
LD08709p; Separase (Sse) encodes an endoprotease. Together with the product of thr, it forms a complex which cleaves a subunit of the cohesin complex during meiosis, thereby allowing separation of the sister chromatids.
   
  
 0.773
Ndc80
LD33040p; Ndc80 (Ndc80) encodes a protein involved in mitotic metaphase plate congression.
   
    0.772
CG7715
LP07818p1; Chitin binding. It is involved in the biological process described with: chitin metabolic process.
   
  
 0.733
CG7714
RH24988p; Chitin binding. It is involved in the biological process described with: chitin metabolic process.
   
  
 0.733
CG34384
Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
   
  
 0.733
tum
Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation.
   
 
 
0.696
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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