node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GATAd | GATAe | FBpp0305311 | FBpp0082672 | GATAd, isoform A; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; cell fate commitment; positive regulation of transcription by RNA polymerase II. | Transcription factor dGATAe; GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. | 0.710 |
GATAd | grn | FBpp0305311 | FBpp0303221 | GATAd, isoform A; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; cell fate commitment; positive regulation of transcription by RNA polymerase II. | Grain, isoform C; Grain (grn) encodes a transcription factor from the GATA family. It regulates the expression of receptors and adhesion molecules such as those encoded by unc-5 and Fas2 involved in axon guidance. It contributes to multiple other developmental processes including leg and larval spiracle morphogenesis. | 0.691 |
GATAd | lz | FBpp0305311 | FBpp0071255 | GATAd, isoform A; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; cell fate commitment; positive regulation of transcription by RNA polymerase II. | Protein lozenge; Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory s [...] | 0.554 |
GATAd | pnr | FBpp0305311 | FBpp0082675 | GATAd, isoform A; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; cell fate commitment; positive regulation of transcription by RNA polymerase II. | GATA-binding factor A; Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes. | 0.664 |
GATAd | srp | FBpp0305311 | FBpp0082669 | GATAd, isoform A; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; cell fate commitment; positive regulation of transcription by RNA polymerase II. | Box A-binding factor; May function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body. Binds a sequence element (5'-[TA]GATAA-3') found in the larval promoters of all known alcohol dehydrogenase (ADH) genes. Acts as a homeotic gene downstream of the terminal gap gene HKB to promote morphogenesis and differentiation of anterior and posterior midgut. | 0.646 |
GATAd | ush | FBpp0305311 | FBpp0302929 | GATAd, isoform A; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; cell fate commitment; positive regulation of transcription by RNA polymerase II. | Zinc finger protein ush; Transcription regulator that modulates expression mediated by transcription factors of the GATA family such as pnr and srp. Represses transcription of proneural achaete-scute complex (AS-C), which is usually activated by pnr. Involved in cardiogenesis, blood, and eye development. During hematopoiesis, it is required to restrict the number of crystal cells, probably via its interaction with the isoform SrpNC of srp. Negatively regulates expression of sr. Probably acts by interacting with the GATA-type zinc finger of proteins such as pnr and srp, possibly antagon [...] | 0.715 |
GATAe | GATAd | FBpp0082672 | FBpp0305311 | Transcription factor dGATAe; GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. | GATAd, isoform A; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; cell fate commitment; positive regulation of transcription by RNA polymerase II. | 0.710 |
GATAe | dpp | FBpp0082672 | FBpp0077453 | Transcription factor dGATAe; GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] | 0.402 |
GATAe | grn | FBpp0082672 | FBpp0303221 | Transcription factor dGATAe; GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. | Grain, isoform C; Grain (grn) encodes a transcription factor from the GATA family. It regulates the expression of receptors and adhesion molecules such as those encoded by unc-5 and Fas2 involved in axon guidance. It contributes to multiple other developmental processes including leg and larval spiracle morphogenesis. | 0.700 |
GATAe | lz | FBpp0082672 | FBpp0071255 | Transcription factor dGATAe; GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. | Protein lozenge; Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory s [...] | 0.643 |
GATAe | pnr | FBpp0082672 | FBpp0082675 | Transcription factor dGATAe; GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. | GATA-binding factor A; Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes. | 0.535 |
GATAe | srp | FBpp0082672 | FBpp0082669 | Transcription factor dGATAe; GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. | Box A-binding factor; May function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body. Binds a sequence element (5'-[TA]GATAA-3') found in the larval promoters of all known alcohol dehydrogenase (ADH) genes. Acts as a homeotic gene downstream of the terminal gap gene HKB to promote morphogenesis and differentiation of anterior and posterior midgut. | 0.563 |
GATAe | ush | FBpp0082672 | FBpp0302929 | Transcription factor dGATAe; GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. | Zinc finger protein ush; Transcription regulator that modulates expression mediated by transcription factors of the GATA family such as pnr and srp. Represses transcription of proneural achaete-scute complex (AS-C), which is usually activated by pnr. Involved in cardiogenesis, blood, and eye development. During hematopoiesis, it is required to restrict the number of crystal cells, probably via its interaction with the isoform SrpNC of srp. Negatively regulates expression of sr. Probably acts by interacting with the GATA-type zinc finger of proteins such as pnr and srp, possibly antagon [...] | 0.640 |
dpp | GATAe | FBpp0077453 | FBpp0082672 | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] | Transcription factor dGATAe; GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. | 0.402 |
dpp | peb | FBpp0077453 | FBpp0099653 | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] | Pebbled, isoform A; Pebbled (peb) encodes a protein that acts as a tissue-specific transcriptional attenuator. It contributes to embryonic morphogenesis and development of ovary, retina and respiratory system. | 0.593 |
dpp | tup | FBpp0077453 | FBpp0080661 | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] | Tailup, isoform A; Tailup (tup) encodes a transcription factor that regulates neuronal sub-type identity, including motor, serotonergic and dopaminergic neuron identity. It regulates germ band retraction, dorsal closure, muscle and heart development. | 0.747 |
dpp | ush | FBpp0077453 | FBpp0302929 | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] | Zinc finger protein ush; Transcription regulator that modulates expression mediated by transcription factors of the GATA family such as pnr and srp. Represses transcription of proneural achaete-scute complex (AS-C), which is usually activated by pnr. Involved in cardiogenesis, blood, and eye development. During hematopoiesis, it is required to restrict the number of crystal cells, probably via its interaction with the isoform SrpNC of srp. Negatively regulates expression of sr. Probably acts by interacting with the GATA-type zinc finger of proteins such as pnr and srp, possibly antagon [...] | 0.629 |
fog | ush | FBpp0305384 | FBpp0302929 | G protein-coupled receptor ligand; Coordinates cell shape changes during formation of the ventral furrow and invagination of the posterior midgut primordium, by inducing apical constriction of cells in spatially and temporally defined manners. Could function as a secreted signal to initiate apical constriction by acting as a ligand for an unidentified G protein- coupled receptor, which in turn activates the G protein alpha subunit encoded by concertina, in neighboring cells. Such an intracellular pathway would ultimately induce contraction of the apical actin-myosin network. In the ven [...] | Zinc finger protein ush; Transcription regulator that modulates expression mediated by transcription factors of the GATA family such as pnr and srp. Represses transcription of proneural achaete-scute complex (AS-C), which is usually activated by pnr. Involved in cardiogenesis, blood, and eye development. During hematopoiesis, it is required to restrict the number of crystal cells, probably via its interaction with the isoform SrpNC of srp. Negatively regulates expression of sr. Probably acts by interacting with the GATA-type zinc finger of proteins such as pnr and srp, possibly antagon [...] | 0.679 |
grn | GATAd | FBpp0303221 | FBpp0305311 | Grain, isoform C; Grain (grn) encodes a transcription factor from the GATA family. It regulates the expression of receptors and adhesion molecules such as those encoded by unc-5 and Fas2 involved in axon guidance. It contributes to multiple other developmental processes including leg and larval spiracle morphogenesis. | GATAd, isoform A; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; cell fate commitment; positive regulation of transcription by RNA polymerase II. | 0.691 |
grn | GATAe | FBpp0303221 | FBpp0082672 | Grain, isoform C; Grain (grn) encodes a transcription factor from the GATA family. It regulates the expression of receptors and adhesion molecules such as those encoded by unc-5 and Fas2 involved in axon guidance. It contributes to multiple other developmental processes including leg and larval spiracle morphogenesis. | Transcription factor dGATAe; GATAe (GATAe) encodes a endoderm-specific GATA factor. It regulates endoderm differentiation and intestinal stem cell maintenance. | 0.700 |