STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ttyProtein tweety; Non-essential protein that probably acts as a chloride channel. (970 aa)    
Predicted Functional Partners:
CG3638
Protein tweety-2; Probable chloride channel; Belongs to the tweety family.
     
0.843
CG14540
Uncharacterized protein; Volume-sensitive chloride channel activity; intracellular calcium activated chloride channel activity.
      
 0.835
na
Narrow abdomen, isoform F; Narrow abdomen (na) encodes an ion channel involved in circadian locomotor rhythms and touch perception.
   
  
 0.633
Task6
TWIK-related acid-sensitive K[+] channel 6 (Task6) encodes an ion channel involved in the transmembrane transport of potassium.
   
  
 0.613
tapas
Tapas, isoform B; It is involved in the biological process described with: negative regulation of transposition; piRNA biosynthetic process.
      
 0.610
para
Sodium channel protein para; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily.
   
  
 0.599
beta4GalNAcTA
beta1,4-N-acetylgalactosaminyltransferase A (beta4GalNAcTA) encodes a acetylgalactosaminyltransferase involved in glycolipid biosynthesis. It contributes to the development of the neuromuscular junction.
      
 0.533
Ork1
Open rectifier K[+] channel 1 (Ork1) encodes a member of the two pore open rectifier potassium channel gene family. It contributes to the regulation of membrane resting potential. The primary gating mechanism for the product of Ork1 appears to be based on phosphorylation of multiple serine, threonine and tyrosine residues in the large intracellular C-terminal tail.
      
 0.461
mmy
Mummy, isoform A; Mummy (mmy) encodes an UDP-N-acetylglucosamine diphosphorylase. It functions in apical extracellular matrix formation by producing GlcNAc residues needed for chitin synthesis and protein glycosylation. It regulates cuticle production, tracheal morphogenesis, and axon guidance.
      
 0.441
CG5946
FAD binding; cytochrome-b5 reductase activity, acting on NAD(P)H. It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; regulation of lipid storage; oxidation-reduction process; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
      
 0.440
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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